System, method and arrangement which can use spectral encoding heterodyne interferometry techniques for imaging

• US 7,859,679 B2
• Filed: 05/31/2006
• Issued: 12/28/2010
• Est. Priority Date: 05/31/2005
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Yelin, Dvir, Bouma, Brett Eugene, Yun, Seok-Hyun, Tearney, Guillermo J.
• Primary Examiner(s): Connolly; Patrick J
• Application Number:
  US11/445,131
• Publication Number:
  US 20060270929A1
• Time in Patent Office: 1,672 Days
• Field of Search: 356/456, 356/479, 356/497
• US Class Current: 356/479
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

Systems, arrangements and methods for obtaining three-dimensional imaging data are provided. For example, a broadband light source can provide a particular radiation. A first electro-magnetic radiation can be focused and diffracted, and then provided to at least one sample to generate a spectrally-encoded line. A second electro-magnetic radiation may be provided to a reference, which may include a double-pass rapidly-scanning optical delay, where the first and second electro-magnetic radiations can be based on the particular radiation. An interference between a third electro-magnetic radiation (associated with the first electro-magnetic radiation) and a fourth electro-magnetic radiation (associated with the second electro-magnetic radiation) can be detected. The spectrally-encoded line may be scanned over the sample in a direction approximately perpendicular to the line. Image data containing three-dimensional information can then be obtained based on the interference. The exemplary imaging methods and systems can be used in a small fiber optic or endoscopic probe.

Claims

1. A system comprising:

at least one first arrangement configured to provide a particular radiation which includes at least one first electro-magnetic radiation directed to at least one sample and at least one second electro-magnetic radiation directed to a reference arrangement, wherein at least one of the at least one first radiation or the at least one second radiation comprises a plurality of wavelengths, and wherein the at least one first arrangement is configured to spectrally disperse the at least one first electro-magnetic radiation along at least one portion of the at least one sample; and

at least one second arrangement configured to generate data is based on the at least one second electromagnetic radiation, wherein the data is axial data that is associated with at least one portion of the at least one sample which is located in a direction that is axial with respect to a direction of the at least one first electro-magnetic radiation.

2. The system according to claim 1, wherein the reference arrangement comprises an optical delay arrangement.

3. The system according to claim 2, wherein the optical delay arrangement is a rapidly-scanning optical delay.

4. The system according to claim 1, wherein the data is further associated with at least one portion of the at least one sample which is located in a direction that is transverse with respect to a direction of the at least one first electro-magnetic radiation.

5. The system according to claim 4, wherein the data is further associated with at least one of a two-dimensional image or a three-dimensional image of at least a portion of the at least one sample.

6. The system according to claim 1, wherein the at least one sample is an anatomical structure.

7. The system according to claim 6, wherein at least a portion of the anatomical structure is provided below a surface of skin.

8. The system according to claim 1, wherein the at least one first arrangement comprises a diffraction grating.

9. The system according to claim 8, wherein the at least one first arrangement further comprises a lens.

10. The system according to claim 9, wherein the at least one first arrangement is further configured to generate a line of radiation on at least a portion of the at least one sample.

11. The system according to claim 10, wherein the at least one first arrangement further comprises at least one scanning arrangement configured to scan the line of radiation in a direction approximately perpendicular to the line.

12. The system according to claim 1, wherein the at least one second arrangement comprises an optical detector.

13. The system according to claim 12, wherein the optical detector includes a charge-couple device.

14. The system according to claim 12, wherein the optical detector is configured to generate a signal based on the at least one first electromagnetic radiation and the at least one second electromagnetic radiation, and wherein the at least one second arrangement is configured to generate a time-frequency transform of the signal.

15. The system according to claim 14, wherein the time-frequency transform is at least one of a short-time Fourier transform, or a Wigner transform.

16. The system according to claim 1, further comprising a processing arrangement configured to provide at least one image based on the data.

17. The system according to claim 16, wherein the at least one processing arrangement is configured to provide the at least one image in real time.

18. The system according to claim 1, wherein the at least one first electromagnetic radiation is provided through a waveguide arrangement.

19. The system according to claim 18, wherein the waveguide arrangement is at least one of a single-mode optical fiber, a multi-mode optical fiber, or a multiple-clad optical fiber.

20. The system according to claim 18, wherein the at least one first arrangement is provided in a probe.

21. The system according to claim 20, wherein the probe comprises at least one of an endoscope or a catheter.

22. A method for generating three-dimensional image data comprising:

providing a particular radiation which includes at least one first electro-magnetic radiation and at least one second electro-magnetic radiation;

directing the at least one first electro-magnetic radiation to at least one sample, wherein the at least one first radiation comprises at least one of a plurality of wavelengths and the at least one first electromagnetic radiation is spectrally dispersed on the at least one sample;

directing the at least one second electro-magnetic radiation to a reference arrangement;

detecting a signal associated with the at least one second electro-magnetic radiation; and

generating image data associated based on the signal, wherein the image data is axial data which is further associated with at least one portion of the at least one sample which is located in a direction that is axial with respect to a direction of the at least one first electro-magnetic radiation.

23. The method of claim 22, wherein the reference arrangement includes an optical delay arrangement.

24. The method of claim 22, wherein the at least one first electromagnetic radiation is provided in the form of a line, and further comprising scanning the line in a direction approximately perpendicular to the line.

25. The method of claim 22, wherein generating the image data comprises generating a time-frequency transform of the signal.

26. The method of claim 25, wherein the time-frequency transform is at least one of a Fourier transform, a short-time Fourier transform, or a Wigner transform.

27. The method of claim 22, further comprising displaying at least one image based on the image data.

28. The method of claim 27, wherein the at least one image is displayed in real time.

29. The method according to claim 23, wherein the optical delay arrangement is a rapidly-scanning optical delay.