Tissue stimulation models, systems, devices, and methods
First Claim
1. A computer-assisted method comprising:
- displaying volumetric imaging data on a display representing an anatomic volume of tissue of a patient;
displaying an indication of a first electrode location of an electrode that has been guided into the anatomic volume;
using a computer model in calculating a volume of influence; and
displaying the calculated volume of influence;
wherein;
the volume of influence includes a predicted volume of tissue affected by an electrical stimulation delivered by the first electrode; and
calculating the volume of influence includes calculating a second difference of a potential distribution to represent the volume of influence.
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Abstract
This document discusses brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. A model computes a volume of influence region for a simulated electrical stimulation using certain stimulation parameters, such as electrode contact selection or location. The model uses a non-uniform tissue conductivity. This accurately represents brain tissue, which has highly directionally conductive neuron pathways yielding a non-homogeneous and anisotropic tissue medium. In one example, a second difference of an electric potential distribution is used to define a volume of activation (VOA) or similar volume of influence. In another example, a neuron or axon model is used to calculate the volume of influence without computing the second difference of the electric potential distribution.
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Citations
16 Claims
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1. A computer-assisted method comprising:
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displaying volumetric imaging data on a display representing an anatomic volume of tissue of a patient; displaying an indication of a first electrode location of an electrode that has been guided into the anatomic volume; using a computer model in calculating a volume of influence; and displaying the calculated volume of influence; wherein; the volume of influence includes a predicted volume of tissue affected by an electrical stimulation delivered by the first electrode; and calculating the volume of influence includes calculating a second difference of a potential distribution to represent the volume of influence. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A non-transitory machine-accessible medium comprising instructions for:
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displaying volumetric imaging data representing an anatomic volume of tissue of a patient; receiving location information about an electrode that has been guided into the anatomic volume represented by the imaging data; displaying an indication of a first electrode location of the electrode in the anatomic volume; using a computer model in calculating a volume of influence; and displaying the calculated volume of influence; wherein; the volume of influence includes a predicted volume of tissue affected by an electrical stimulation delivered by the first electrode; and calculating the volume of influence includes calculating a second difference of a potential distribution to represent the volume of influence. - View Dependent Claims (8, 9, 10, 11)
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12. A system comprising:
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an imaging data storage circuit configured to store volumetric imaging data representing an anatomic volume of tissue of a patient; an electrode position interface circuit configured to receive information about an indication of an electrode location of an electrode that has been inserted into the anatomic volume; a processor circuit, coupled to the imaging data storage circuit and the electrode position interface circuit, the processor circuit producing a computer model configured for calculating a volume of influence; and a display coupled to the processor circuit, the display configured to display the indication of the electrode location and the calculated volume of influence; wherein; the volume of influence includes a predicted volume of tissue affected by electrical stimulation delivered by the electrode; and calculating the volume of influence includes calculating a second difference of a potential distribution to represent the volume of influence. - View Dependent Claims (13, 14, 15, 16)
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Specification