CNS assay for prediction of therapeutic efficacy for neuropathic pain and other functional illnesses
First Claim
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1. A method for identifying a therapeutic intervention for a functional illness, said method comprising the steps of:
- (a) administering a candidate therapeutic intervention to a subject;
(b) administering an acute painful stimulus to said subject; and
(c) measuring a level of activation of the central nervous system (CNS) indicative of said functional illness in said subject, wherein a modification of said level of CNS activation relative to a control level of activation characteristic of said functional illness is indicative of the efficacy of said candidate therapeutic intervention for said functional illness, wherein said level of activation is not measured with reference to specific regions of the CNS.
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Abstract
In general, the invention features methods for identifying therapeutic interventions for functional illnesses, e.g., neuropathic pain or depression, and methods for identifying markers for functional illnesses by employing an acute painful stimulus or other stimulus for a functional illness and measuring levels of CNS activity.
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13 Claims
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1. A method for identifying a therapeutic intervention for a functional illness, said method comprising the steps of:
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(a) administering a candidate therapeutic intervention to a subject; (b) administering an acute painful stimulus to said subject; and (c) measuring a level of activation of the central nervous system (CNS) indicative of said functional illness in said subject, wherein a modification of said level of CNS activation relative to a control level of activation characteristic of said functional illness is indicative of the efficacy of said candidate therapeutic intervention for said functional illness, wherein said level of activation is not measured with reference to specific regions of the CNS. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for identifying a therapeutic intervention for a psychiatric disorder, said method comprising the steps of:
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(a) administering a candidate therapeutic intervention to a subject; (b) administering an acute painful stimulus for said psychiatric disorder to said subject; and (c) measuring the level of CNS activation in said subject, wherein a modification of said level of CNS activation relative to a control level of CNS activation characteristic of said psychiatric disorder is indicative of the efficacy of said candidate therapeutic intervention for said psychiatric disorder, wherein said level of activation is not measured with reference to specific regions of the CNS. - View Dependent Claims (9, 10, 11, 12, 13)
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Specification