Cardiac neuromodulation and methods of using same

• US 7,860,563 B2
• Filed: 11/23/2005
• Issued: 12/28/2010
• Est. Priority Date: 04/20/2001
• Status: Active Grant

• Current Assignee: The Board of Regents of the University of Colorado (University of Colorado System)
• Original Assignee: The Board of Regents of the University of Colorado (University of Colorado System)
• Inventors: DeJongste, Michael J. L., Ardell, Jeffrey L., Armour, John A., Foreman, Robert D., Linderoth, Bengt G. S.
• Primary Examiner(s): Schaetzle; Kennedy J
• Application Number:
  US11/287,094
• Publication Number:
  US 20060111746A1
• Time in Patent Office: 1,861 Days
• Field of Search: None
• US Class Current: 607/2
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension

Abstract

The present invention relates in general to methodologies for the treatment quenching preconditioning and communication between the intrinsic cardiac nervous system and an electrical stimulus. In particular, the present invention utilizes spinal cord stimulation to alter and/or affect the intrinsic cardiac nervous system and thereby protect the myocytes, stabilize myocardial electrical instability and/or alleviate or diminish cardiac pathologies.

Claims

1. A method of preemptively treating myocardial ischemia in a patient comprising:

identifying a patient susceptible to myocardial ischemia;

implanting a stimulation device into the patient to electrically stimulate the spinal cord, wherein the stimulation device comprises a plurality of electrodes and a generator in which at least one electrode is placed near the spinal cord;

activating the stimulation device to deliver electrical stimulation to the spinal cord to suppress intrinsic cardiac nerve activity thereby preemptively treating myocardial ischemia.

2. The method of claim 1, wherein the electrical stimulation stabilizes the adrenergic neurons.

3. The method of claim 1, wherein the electrical stimulation stabilizes cardiomyocytes.

4. The method of claim 1, wherein the electrical stimulation alters catecholamine release.

5. The method of claim 1, wherein the electrical stimulation stabilizes the electrical activity of the heart.

6. The method of claim 1, wherein the electrical stimulation stabilizes the mechanical activity of the heart.

7. The method of claim 6 wherein stabilizing the mechanical activity of the heart reduces the progression of heart failure.

8. The method of claim 6 wherein stabilizing the mechanical activity of the heart reduces deleterious cardiac remodeling.

9. The method of claim 6 wherein mechanical dyssynchrony is reduced.

10. The method of claim 6 wherein stabilizing the mechanical activity of the heart reduces ventricular tachycardias, ventricular fibrillations, premature ventricular contractions or a combination thereof.

11. The method of claim 1, wherein the electrical stimulation reduces deleterious cardiac remodeling.

12. The method of claim 1, wherein the electrical stimulation stabilizes the activity of the autonomic nervous system.

13. The method of claim 1, wherein the electrical stimulation is preformed prior to an ischemic event.

14. A method of treating myocardial ischemia in a patient comprising:

identifying a patient suffering from or is susceptible to myocardial ischemia;

implanting a stimulation device into the patient to electrically stimulate the spinal cord, wherein the stimulation device comprises a plurality of electrodes and a generator in which at least one electrode is placed near the upper cervical spinal cord;

activating the stimulation device to deliver electrical stimulation to the spinal cord to suppress intrinsic cardiac nerve activity thereby treating myocardial ischemia.

15. A method of providing cardioprotection:

identifying a subject susceptible to or suffering from a cardiac pathology;

implanting a stimulation device into the identified patient to electrically stimulate the spinal cord, wherein the stimulation device comprises a plurality of electrodes and a generator in which at least one electrode is placed near the spinal cord;

activating the stimulation device to deliver electrical stimulation to the spinal cord, wherein electrical stimulation of the spinal cord suppresses intrinsic cardiac nerve activity thereby providing cardioprotection.