Method of making an electrochemical sensor
First Claim
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1. A method of manufacturing an in vitro sensor for the determination of the presence and/or level of glucose in a sample, the sensor comprising:
- forming at least one conductive trace on a substrate by non impact printing, including applying a conductive material on the substrate to provide one or more traces including the at least one conductive trace to form one or more electrodes, at least one trace having a width of about 25 microns to 250 microns, and the substrate comprising a first portion that is narrower than a second portion;
wherein the in vitro sensor is configured to determine the presence and/or level of glucose in a volume sample of about 1 microliter or less.
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Abstract
A process for the manufacture of small sensors with reproducible surfaces, including electrochemical sensors. One process includes forming channels in the surface of a substrate and disposing a conductive material in the channels to form an electrode. The conductive material can also be formed on the substrate by other impact and non-impact methods. In a preferred embodiment, the method includes cutting the substrate to form a sensor having a connector portion and a transcutaneous portion, the two portions having edges that define one continuous straight line.
259 Citations
20 Claims
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1. A method of manufacturing an in vitro sensor for the determination of the presence and/or level of glucose in a sample, the sensor comprising:
forming at least one conductive trace on a substrate by non impact printing, including applying a conductive material on the substrate to provide one or more traces including the at least one conductive trace to form one or more electrodes, at least one trace having a width of about 25 microns to 250 microns, and the substrate comprising a first portion that is narrower than a second portion; wherein the in vitro sensor is configured to determine the presence and/or level of glucose in a volume sample of about 1 microliter or less. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of manufacturing an in vitro sensor for the determination of the presence and/or level of glucose in a sample, the sensor comprising:
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forming at least one conductive trace on a substrate by non impact printing, including applying a conductive material on the substrate to provide one or more traces including the at least one conductive trace to form one or more electrodes, at least one trace having a width of about 25 microns to 250 microns; and providing an indentation in the substrate; wherein the in vitro sensor is configured to determine the presence and/or level of glucose in a volume sample of about 1 microliter or less. - View Dependent Claims (14, 15, 16)
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17. A method of manufacturing an in vitro sensor for the determination of the presence and/or level of glucose in a sample, the sensor comprising:
forming at least one conductive trace on a substrate by non impact printing, including applying a conductive material on the substrate to provide one or more traces including the at least one conductive trace to form one or more electrodes, at least one trace having a width of about 25 microns to 250 microns; wherein the in vitro sensor is configured to determine the presence and/or level of glucose in a volume sample of about 1 microliter or less; and
furtherwherein the sensor comprises a skin piercer. - View Dependent Claims (18, 19, 20)
Specification