Coated implantable medical device
First Claim
1. An implantable medical device, comprising a stent graft comprising:
- an expandable stent in combination with a graft formed of a base material sized and shaped for introduction into a vascular system of a patient, the graft having at least one surface;
a coating layer comprising a first polymer posited between the at least one surface of the graft and at least one bioactive layer;
the at least one bioactive layer comprising a bioactive agent posited over the at least one surface of the graft and under a porous layer;
the porous layer comprising a second polymer posited over the bioactive agent and controlling the release of the bioactive agent, the first polymer and the second polymer being the same or different.
3 Assignments
0 Petitions
Accused Products
Abstract
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of a bioactive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of bioactive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of bioactive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a stent graft. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.
239 Citations
12 Claims
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1. An implantable medical device, comprising a stent graft comprising:
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an expandable stent in combination with a graft formed of a base material sized and shaped for introduction into a vascular system of a patient, the graft having at least one surface; a coating layer comprising a first polymer posited between the at least one surface of the graft and at least one bioactive layer; the at least one bioactive layer comprising a bioactive agent posited over the at least one surface of the graft and under a porous layer; the porous layer comprising a second polymer posited over the bioactive agent and controlling the release of the bioactive agent, the first polymer and the second polymer being the same or different. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification