Method of manufacturing a medical device having a porous coating thereon
First Claim
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1. A method of manufacturing a coated medical device having a coating containing fissures, the method comprising:
- providing a medical device;
preparing a mixture comprising a solvent, a drug, and a polymer;
dispersing solid particle additives in the mixture to form a suspension comprising dispersed solid particle additives;
applying the suspension on the medical device to form a coating containing fissures on the medical device; and
evaporating the solvent to shrink the coating and cause the mixture to separate from the solid particle additives, thereby creating the fissures in the coating on the medical device,wherein the solid particle additives remain in the coating during use of the medical device in the body,wherein the solid particle additives and the drug are not both bone morphogenic proteins, andwherein the solid particle additives are a separate component from the drug.
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Abstract
Methods of manufacturing drug-coated medical devices having a porous coatings thereon. The pores are created by solid particle additives added to a mixture comprising a solvent, a drug, and a polymer to create a suspension, which is applied to the medical device. The method includes adding a surfactant to the mixture to prevent or decrease flocculation of the solid particle additives. Another method is provided that includes spraying a suspension on a medical device that comprises solid particle additives, a drug, and a polymer and analyzing the distribution of the solid particle additives in the suspension.
24 Citations
27 Claims
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1. A method of manufacturing a coated medical device having a coating containing fissures, the method comprising:
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providing a medical device; preparing a mixture comprising a solvent, a drug, and a polymer; dispersing solid particle additives in the mixture to form a suspension comprising dispersed solid particle additives; applying the suspension on the medical device to form a coating containing fissures on the medical device; and evaporating the solvent to shrink the coating and cause the mixture to separate from the solid particle additives, thereby creating the fissures in the coating on the medical device, wherein the solid particle additives remain in the coating during use of the medical device in the body, wherein the solid particle additives and the drug are not both bone morphogenic proteins, and wherein the solid particle additives are a separate component from the drug. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification