Isolation of skeletal precursor cells
First Claim
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1. A method of identifying viable, expanded or passaged, committed skeletal precursor cells capable of differentiating into skeletal tissues comprising the step of:
- detecting the expression of cartilage-derived morphogenic protein-1 (CDMP-1) in an in vitro cell culture of cells obtained from human periosteum, synovial membrane or bone marrow,wherein the expression of CDMP-1 identifies skeletal precursor cells.
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Abstract
Cartilage-derived morphogenetic protein CDMP-1 or a transforming growth factor β having at least 80% homology with CDMP-1, or a factor co-expressed and/or co-detectable therewith, is used as a marker of skeletal precursor cells from any part of a mammalian body.
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Citations
8 Claims
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1. A method of identifying viable, expanded or passaged, committed skeletal precursor cells capable of differentiating into skeletal tissues comprising the step of:
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detecting the expression of cartilage-derived morphogenic protein-1 (CDMP-1) in an in vitro cell culture of cells obtained from human periosteum, synovial membrane or bone marrow, wherein the expression of CDMP-1 identifies skeletal precursor cells. - View Dependent Claims (2, 3, 4)
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5. A method of obtaining a homogenous culture of viable, expanded or passaged, committed skeletal precursor cells capable of differentiating into skeletal tissues comprising the steps of:
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a) detecting the expression of cartilage-derived morphogenic protein-1 (CDMP-1) in an in vitro cell culture of cells obtained from human periosteum, synovial membrane or bone marrow; and b) selecting or enriching CDMP-1 positive cells, thereby producing a homogenous culture of skeletal precursor cells capable of differentiating into skeletal tissue. - View Dependent Claims (6, 7, 8)
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Specification