Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties

• US 7,865,231 B2
• Filed: 05/01/2002
• Issued: 01/04/2011
• Est. Priority Date: 05/01/2001
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Bouma, Brett Eugene, Tearney, Guillermo J.
• Primary Examiner(s): Casler; Brian
• Assistant Examiner(s): RAMIREZ, JOHN FERNANDO
• Application Number:
  US10/137,749
• Publication Number:
  US 20030028100A1
• Time in Patent Office: 3,170 Days
• Field of Search: 600478-480, 600/476, 600/407, 600/549, 600/473
• US Class Current: 600/476
• CPC Class Codes: A61B 1/00165 with light-conductive means, e.g. fibre optics A61B1/07 takes precedence
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: G01B 2290/70 Using polarization in the interferometer
• CPC Class Codes: G01B 9/02007 Two or more frequencies or sources used for interferometric measurement using only beat G01B9/02003
• CPC Class Codes: G01B 9/02014 by using pulsed light
• CPC Class Codes: G01B 9/02072 by calibration or testing of interferometer
• CPC Class Codes: G01B 9/02083 characterised by particular signal processing and presentation
• CPC Class Codes: G01B 9/02088 Matching signals with a database
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence

Abstract

Methods for diagnosing vulnerable atherosclerotic plaque using optical coherence tomography to measure tissue optical properties, including backreflectance of heterogeneous layers, such as plaque cap, lipid pool composition and macrophage presence. Methods also include measurement of spatially and temporally dependent reflectance, measurement of multiple wavelength reflectance, low coherence interferometry, polarization and quantification of macrophage content.

Claims

1. An apparatus for obtaining at least one quantitative characteristic associated with at least one plaque structure, comprising:

at least one first arrangement which is configured to receive at least one interferometric signal which results from a combination of at least one first electromagnetic radiation returned from the at least one plaque structure and at least one second electromagnetic radiation returned from a reference, wherein the at least one first arrangement is configured to generate at least one further signal which is associated with the at least one interferometric signal; and

at least one second arrangement which is configured to determine the at least one quantitative characteristic of the at least one plaque structure as a function of the at least one further signal, wherein the at least one quantitative characteristic associated with the at least one plaque structure comprises a concentration of a substance within the at least one plaque structure.

2. The apparatus according to claim 1, wherein the at least one characteristic includes at least one of a thickness, a spatial distribution or a concentration of at least one substance within at least one cap.

3. The apparatus according to claim 1, wherein the at least one characteristic includes at least one a quantity, a type or a spatial distribution of at least one collagen.

4. The apparatus according to claim 1, wherein the at least one characteristic includes at least one of a presence, a quantity, a type or a spatial distribution of at least one smooth muscle cell.

5. The apparatus according to claim 1, wherein the at least one characteristic includes at least one of a presence, a quantity, a type or a spatial distribution of at least one of (i) intima, (ii) intimal hyperplasia, (iii) media, (iv) adventitia, (v) internal elastic lamina, (vi) external elastic lamina, (vii) calcification, (viii) dissection, (ix) thrombus, or (x) erosion.

6. The apparatus according to claim 1, wherein the at least one characteristic includes at least one optical property of the plaque structure, and wherein the at least one optical property includes at least one of a scattering coefficient or an absorption coefficient.

7. The apparatus according to claim 1, wherein the at least one second arrangement is further configured to generate image data associated with at least one image of at least one portion of the at least one plaque structure as a function of the at least one further signal, and wherein the at least one characteristic is determined as a further function of the data.

8. The apparatus according to claim 1, wherein the at least one characteristic includes at least one of a presence, a quantity or a spatial distribution of at least one macrophage.

9. The apparatus according to claim 1, wherein the at least one second arrangement is configured to determine signal information which is at least one of a signal standard deviation, a signal variance, or a probability distribution function statistic of the at least one portion of the at least one image, and wherein the information is related to the at least one of the presence, the quantity or the spatial distribution of at least one macrophage.

10. The apparatus according to claim 9, wherein the at least one second arrangement generates at least one image as a function of the signal information.

11. The apparatus according to claim 9, wherein the information includes at least one of collagen, smooth muscle cell, or cholesterol crystals.

12. The apparatus according to claim 1, wherein the at least one second arrangement compares at least one of the at least one characteristic of the signal information to at least one predetermined information regarding the at least one plaque structure so as to determine whether at least one abnormality is present.

13. The apparatus according to claim 12, wherein the at least one second arrangement generates at least one image as a function of the signal information.

14. The apparatus according to claim 12, wherein the information includes at least one of collagen, smooth muscle cell, or cholesterol crystals.

15. The apparatus according to claim 1, further comprising at least one further arrangement which is configured to determine at least one characteristic of the at least one plaque structure as a function of the birefringence of the at least one plaque structure.

16. The apparatus according to claim 1, wherein the at least one plaque structure is at least one anatomical structure.

17. The apparatus according to claim 16, wherein the at least one arrangement is configured to generate data that is usable for producing at least one image of the at least one anatomical structure based on the information.

18. The apparatus according to claim 16, wherein the first and second ones of the at least one first electromagnetic radiation are image signals.

19. The apparatus according to claim 1, wherein the at least one second arrangement is configured to determine a signal information associated with a normalized signal intensity of the at least one portion of the at least one image, and wherein the information is related to the at least one of the presence, the quantity or the spatial distribution of at least one macrophage.

20. The apparatus according to claim 1, wherein the concentration of the substance is associated with depth information of the at least one plaque structure.

21. An apparatus for obtaining at least one quantitative characteristic associated with at least one plaque anatomical structure, comprising:

at least one first arrangement which is configured to receive at least one interferometric signal which results from a combination of at least one first electromagnetic radiation returned from the at least one plaque anatomical structure and at least one second electromagnetic radiation returned from a reference, wherein the at least one first arrangement is configured to generate at least one further signal which is associated with the at least one interferometric signal; and

at least one second arrangement which is configured to determine the at least one quantitative characteristic of the at least one plaque anatomical structure as a function of the at least one further signal, wherein the at least one quantitative characteristic associated with the at least one plaque anatomical structure comprises at least one of (i) a dimensional characteristic associated with the at least one plaque anatomical structure or (ii) a concentration of a substance within the at least one plaque anatomical structure, wherein a first one of the at least one first electromagnetic radiation is at least partially returned from a first depth of the at least one plaque anatomical structure, wherein a second one of the at least one first electromagnetic radiation is at least partially returned from a second depth of the at least one anatomical structure, and wherein the first depth is different from the second depth, and wherein the at least one arrangement is configured to determine data associated with a spatial location of the at least one plaque anatomical structure within a sample based on the a combination of the first and second ones of the at least one first electromagnetic radiation.

22. A method for obtaining at least one quantitative characteristic associated with at least one plaque structure, comprising:

receiving at least one interferometric signal which results from a combination of at least one first electromagnetic radiation returned from the at least one plaque structure and at least one second electromagnetic radiation returned from a reference;

generating at least one further signal which is associated with the at least one interferometric signal; and

determining the at least one quantitative characteristic of the at least one plaque structure as a function of the at least one further signal, wherein the at least one quantitative characteristic associated with the at least one plaque structure comprises a concentration of a substance within the at least one plaque structure.

23. The method according to claim 22, wherein the at least one characteristic includes at least one of a thickness, a spatial distribution or a concentration of at least one substance within at least one cap.

24. The method according to claim 22, wherein the at least one characteristic includes at least one a quantity, a type or a spatial distribution of at least one collagen.

25. The method according to claim 22, wherein the at least one characteristic includes at least one of a presence, a quantity, a type or a spatial distribution of at least one smooth muscle cell.

26. The method according to claim 22, wherein the at least one characteristic includes at least one optical property of the plaque structure, and wherein the at least one optical property includes at least one of a scattering coefficient or an absorption coefficient.

27. The method according to claim 22, wherein the at least one characteristic includes at least one of a presence, a quantity or a spatial distribution of at least one macrophage.

28. The method according to claim 22, wherein the at least one second arrangement is configured to determine signal information which is at least one of a signal standard deviation, a signal variance, or a probability distribution function statistic of the at least one portion of the at least one image, and wherein the information is related to the at least one of the presence, the quantity or the spatial distribution of at least one macrophage.

29. The method according to claim 22, wherein the at least one plaque structure is at least one anatomical structure.

30. The method according to claim 22, wherein the concentration of the substance is associated with depth information of the at least one plaque structure.

31. A method for obtaining at least one quantitative characteristic associated with at least one plaque anatomical structure, comprising:

receiving at least one interferometric signal which results from a combination of at least one first electromagnetic radiation returned from the at least one plaque anatomical structure and at least one second electromagnetic radiation returned from a reference;

generating at least one further signal which is associated with the at least one interferometric signal; and

determining the at least one quantitative characteristic of the at least one plaque structure as a function of the at least one further signal, wherein the at least one quantitative characteristic associated with the at least one plaque anatomical structure comprises at least one of (i) a dimensional characteristic associated with the at least one plaque anatomical structure or (ii) a concentration of a substance within the at least one plaque anatomical structure,

wherein the at least one plaque structure is at least one anatomical structure,

wherein a first one of the at least one first electromagnetic radiation is at least partially returned from a first depth of the at least one plaque anatomical structure,

wherein a second one of the at least one first electromagnetic radiation is at least partially returned from a second depth of the at least one plaque anatomical structure, wherein the first depth is different from the second depth, and

wherein the at least one arrangement is configured to determine data associated with a spatial location of the at least one plaque anatomical structure within a sample based on the a combination of the first and second ones of the at least one first electromagnetic radiation.