Immunoglobulin fusion proteins
First Claim
Patent Images
1. A polypeptide represented by the following formula:
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N′
—
(Z1)p—
Y—
Z2—
Z3—
Z4—
C′
wherein N′
is the N-terminus and C′
is the C-terminus of the polypeptide,Z1 is an amino acid sequence consisting of the amino acid residues at positions 90 to 98 of SEQ ID NO;
14;
Y is an amino acid sequence consisting of 5 or more consecutive amino acid residues from the C-terminus at positions 99 to 162 of SEQ ID NO;
14;
Z2 is an amino acid sequence consisting of the amino acid residues at positions 163 to 170 of SEQ ID NO;
14;
Z3 is an amino acid sequence consisting of the amino acid residues at positions 121 to 220 of SEQ ID NO;
13;
Z4 is an amino acid sequence consisting of the amino acid residues at positions 221 to 327 of SEQ ID NO;
13; and
p is an integer of 0 or 1.
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Abstract
Disclosed are fusion proteins comprising a biologically active molecule and an immunoglobulin (Ig) Fc domain which is linked to the biologically active molecule. The Fc domain is a hybrid human Fc domain of (i) IgG1, IgG2 or IgG4 or (ii) IgG4 and IgD. The hybrid Fc is useful as a carrier of biologically active molecules.
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Citations
26 Claims
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1. A polypeptide represented by the following formula:
-
N′
—
(Z1)p—
Y—
Z2—
Z3—
Z4—
C′wherein N′
is the N-terminus and C′
is the C-terminus of the polypeptide,Z1 is an amino acid sequence consisting of the amino acid residues at positions 90 to 98 of SEQ ID NO;
14;Y is an amino acid sequence consisting of 5 or more consecutive amino acid residues from the C-terminus at positions 99 to 162 of SEQ ID NO;
14;Z2 is an amino acid sequence consisting of the amino acid residues at positions 163 to 170 of SEQ ID NO;
14;Z3 is an amino acid sequence consisting of the amino acid residues at positions 121 to 220 of SEQ ID NO;
13;Z4 is an amino acid sequence consisting of the amino acid residues at positions 221 to 327 of SEQ ID NO;
13; andp is an integer of 0 or 1. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification