Integrated chip carriers with thermocycler interfaces and methods of using the same
First Claim
1. A carrier for holding a microfluidic device comprising:
- a non-elastomeric substrate comprising a plurality of wells, wherein each of the plurality of wells has a well opening with a center point and the plurality of wells is spatially arranged such that the center point to center point spacing is about 4.5 mm;
a plurality of channels within the substrate wherein each of the plurality of wells is in fluid communication with at least one of the plurality of channels; and
a receiving portion on the non-elastomeric substrate for receiving the microfluidic device and placing the microfluidic device in fluid communication with the plurality of wells, wherein the microfluidic device comprises an elastomeric material.
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Accused Products
Abstract
Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.
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Citations
16 Claims
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1. A carrier for holding a microfluidic device comprising:
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a non-elastomeric substrate comprising a plurality of wells, wherein each of the plurality of wells has a well opening with a center point and the plurality of wells is spatially arranged such that the center point to center point spacing is about 4.5 mm; a plurality of channels within the substrate wherein each of the plurality of wells is in fluid communication with at least one of the plurality of channels; and a receiving portion on the non-elastomeric substrate for receiving the microfluidic device and placing the microfluidic device in fluid communication with the plurality of wells, wherein the microfluidic device comprises an elastomeric material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A carrier for holding a microfluidic device, the carrier comprising:
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a carrier substrate comprising at least a plurality of wells, wherein each of the plurality of wells has an exposed top opening to receive a fluid from outside the carrier, and wherein each of the plurality of wells has a center point and the plurality of wells are spatially arranged such that the center point to center point spacing is about 4.5 mm; a plurality of channels within the carrier substrate wherein each of the plurality of wells is in fluid communication with at least one of the plurality of channels; and a receiving portion on the carrier substrate for receiving the microfluidic device and placing the microfluidic device in fluid communication with the plurality of wells.
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15. A carrier for holding a microfluidic device, the carrier comprising:
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a carrier substrate comprising at least a plurality of wells, wherein each of the plurality of wells has a center point and the plurality of wells are spatially arranged such that the center point to center point spacing is about 4.5 mm; a plurality of channels within the carrier substrate, wherein each of the channels has a first terminus that is fluidly coupled to one of the plurality of wells and a second terminus operable to be fluidly coupled to the microfluidic device; and a receiving portion on the carrier substrate for receiving the microfluidic device and coupling the microfluidic device to the second termini of the plurality of channels to place the microfluidic device in fluid communication with the plurality of wells. - View Dependent Claims (16)
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Specification