BH3 peptides and method of use thereof

• US 7,868,133 B2
• Filed: 04/24/2007
• Issued: 01/11/2011
• Est. Priority Date: 09/09/2002
• Status: Active Grant

• Current Assignee: Dana-Farber Cancer Institute
• Original Assignee: Dana-Farber Cancer Institute
• Inventors: Letai, Anthony, Korsmeyer, Stanley J.
• Primary Examiner(s): Yu; Misook
• Assistant Examiner(s): Yao; Lei
• Application Number:
  US11/789,557
• Publication Number:
  US 20080234201A1
• Time in Patent Office: 1,358 Days
• Field of Search: None
• US Class Current: 530/300
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07K 14/4747 Apoptosis related proteins
• CPC Class Codes: C07K 2319/03 containing a transmembrane segment

Abstract

The invention provides peptides and the nucleic acid sequences that encode them. The invention further provides therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of apoptosis associated disorders.

Claims

1. An isolated peptide of 50 amino acids or fewer comprising the amino acid sequence of SEQ ID NO:

6.

2. The peptide of claim 1, wherein said peptide binds or MCL-1.

6. A composition comprising a peptide of any one of claims 1-5 and a carrier.

3. An isolated peptide of SEQ ID NO:

6.

4. A chimeric peptide comprising a first domain and a second domain wherein said first domain comprises the amino acid sequence consisting of SEQ ID NO:

6 and said second domain comprises a translocation sequence which facilitates transport across a biological membrane.

5. The peptide of claim 4, wherein said translocation sequence is polyarginine.