Mass spectrometer ion guide providing axial field, and method

• US 7,868,289 B2
• Filed: 04/30/2007
• Issued: 01/11/2011
• Est. Priority Date: 04/30/2007
• Status: Active Grant

• Current Assignee: PerkinElmer Scientific Canada ULC (Revvity, Inc.)
• Original Assignee: Ionics Mass Spectrometry Group Inc.
• Inventors: Cousins, Lisa, Tomski, Ilia, Javahery, Gholamreza
• Primary Examiner(s): Wells; Nikita
• Assistant Examiner(s): Smith; Johnnie L
• Application Number:
  US11/742,203
• Publication Number:
  US 20080265154A1
• Time in Patent Office: 1,352 Days
• Field of Search: 250/292, 250/396.R
• US Class Current: 250/292
• CPC Class Codes: H01J 49/063 Multipole ion guides, e.g. quadrupoles, hexapoles

Abstract

An ion guide includes a plurality of rods, arranged about an axis that extends lengthwise from one end to the other of the guide. The rods guide ions in a guide region along and about the axis. A conductive casing surrounds the rods. The casing and the rods are geometrically arranged to produce an axial electric field along the axis. Specifically, the geometry is such that a first constant applied DC voltage (U_DC), applied to the rods, and a second constant applied DC voltage (U_CASE) applied to the casing, produce a voltage gradient between said casing and said axis that has a different magnitude at different positions along said axis.

Claims

1. An ion guide comprising:

a plurality of parallel rods, arranged in multipole about an axis that extends lengthwise from a first end to a second end of said ion guide, to guide ions in a guide region along and about said axis;

wherein each of said plurality of rods has a generally rectangular cross-section and is tapered along its length;

a conductive cylindrical casing surrounding said plurality of rods;

at least one voltage source, interconnected to said plurality of rods and to said casing to produce an axial electric field along said axis.

2. The ion guide of claim 1, wherein said at least one voltage source provides a time varying voltage to said conductive casing.

3. The ion guide of claim 1, wherein said at least one voltage source provides a DC voltage to said conductive casing to produce said field.

4. The ion guide of claim 1, wherein each of said rods comprises a plurality of rod segments.

5. An ion guide comprising:

a plurality of parallel rods, arranged about an axis that extends lengthwise from a first end to a second end of said ion guide, to guide ions in a guide region along and about said axis;

a conductive cylindrical casing surrounding said plurality of rods;

wherein each of said plurality of rods has a generally rectangular cross-section and is tapered along its length;

wherein said casing and said plurality of rods are geometrically arranged so that a first constant applied DC voltage (U_DC) applied to said rods, and a second constant applied DC voltage (U_CASE) applied to said conductive casing, produce a voltage gradient between said casing and said axis that has a different magnitude at different positions along said axis, to produce an axial electric field along said axis.

6. The ion guide of claim 5, maintained at a pressure between about 10⁻

4 and 10<sup>−

2</sup> Torr.

7. The ion guide of claim 5, maintained at a pressure between about 10⁻

4 and 10 Torr.

8. The ion guide of claim 5, wherein four rods are arranged in quadrupole about said axis.

9. The ion guide of claim 5, wherein six rods are arranged in hexapole about said axis.

10. The ion guide of claim 5, wherein said rods are formed as shims.

11. The ion guide of claim 5, wherein said conductive casing has a conductive inner surface.

12. The ion guide of claim 5, wherein said conductive casing comprises a focusing lens at each end, to allow said on guide to function as a collision cell.

13. The ion guide of claim 5, wherein eight rods are arranged in octopole about said axis.

14. A mass spectrometer comprising the ion guide of claim 5.

20. The ion guide of claim 5, wherein each of said rods has a straight edge, parallel to said axis.

21. The ion guide of claim 5, wherein each of said plurality of rods has two parallel edges parallel to said axis, and wherein the width of each of said plurality of rods extends radially relative to said axis, and the width of each of said rods is tapered along its length.

22. The ion guide of claim 5, wherein each of said plurality of rods has a width and a height, and wherein the height of each of said plurality of rods is constant along its length.

15. A method comprising:

providing a plurality of parallel rods about an axis that extends lengthwise from a first end to a second end to guide ions in a guide region along and about said axis;

providing a conductive cylindrical casing surrounding said plurality of rods;

creating a multipolar electric field between said plurality of rods to contain ions in said guide region;

applying a substantially DC voltage to said conductive casing and said rods,

wherein each of said plurality of rods has a generally rectangular cross-section and is tapered along its length;

wherein said casing and said plurality of rods are geometrically arranged so that said substantially DC voltage to said casing and said rods, produce a voltage gradient between said casing and said axis that has a different magnitude at different positions along said axis, to produce an axial electric field along said axis.

16. The method of claim 15, wherein said providing comprises providing four rods about said axis.

17. The method of claim 15, wherein said creating a multipolar electric field between said plurality of rods comprises applying a sinusoidal voltage across opposite ones of said plurality of rods.

18. The method of claim 15, further comprising adjusting said substantially DC voltage applied to said rods and said casing, in dependence on ions to be guided by said rods, in order to assist in fragmentation of said ions.

19. The method of claim 15, wherein said at least one voltage source applies a different DC voltages to different rod segments forming one of said rods.

23. An ion guide comprising:

a plurality of parallel rods, arranged in multipole about an axis that extends lengthwise from a first end to a second end of said ion guide to guide ions in a guide region along and about said axis;

wherein each of said plurality of rods is oriented parallel to said axis, and has a slot extending along its length, and wherein the size of each slot varies along its lengthwise extent;

a conductive cylindrical casing surrounding said plurality of rods;

at least one voltage source, interconnected to said plurality of rods and to said casing to produce an axial electric field along said axis.

24. The ion guide of claim 23, wherein each of said slots is tapered along its lengthwise extent.

25. The ion guide of claim 24, wherein each of said slots is narrower proximate said first end than said second end.