Pacing therapy for diastolic heart failure

• US 7,869,871 B2
• Filed: 03/31/2006
• Issued: 01/11/2011
• Est. Priority Date: 03/31/2006
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Alvarez, Guy, Lovett, Eric G., Salo, Rodney W.
• Primary Examiner(s): Manuel; George
• Assistant Examiner(s): Wieland; Robert N
• Application Number:
  US11/278,330
• Publication Number:
  US 20070239219A1
• Time in Patent Office: 1,747 Days
• Field of Search: 607/9, 607/32, 600/486
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36528 the parameter being measured by means of ultrasound
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

Described herein are methods and systems for delivering pacing therapy to HF patients who do not exhibit a reduced EF. Such patients do not have systolic dysfunction and generally do not benefit from established HF therapies that either augment contractile function or counteract conduction abnormalities. In one embodiment, a HF patient with a normal EF is tested for the adequacy of heart rate response during exercise. If the patient is found to be chronotropically incompetent, a rate-adaptive pacing mode is employed in order to improve functional capacity.

Claims

1. A cardiac pacing system comprising:

a sensing circuit to sense at least one cardiac signal;

a pacing circuit to deliver pacing pulses;

an exertion level sensor;

a diastolic performance sensor to sense a signal indicative of a diastolic function that relates to how optimally the ventricles are filling with blood during diastole;

a signal processor adapted to receive and process the signal indicative of the diastolic function, the signal processor including a diastolic performance parameter generator to produce a diastolic performance parameter based on the signal indicative of the diastolic function;

a pacing controller coupled to the sensing circuit and the pacing circuit, the pacing controller being programmed to deliver paces with a rate-adaptive pacing mode based upon signals from the exertion level sensor wherein a rate-adaptive algorithm maps the exertion level signals to a modified pacing rate in accordance with a rate-response function;

wherein the pacing controller is programmed to determine if diastolic filling is compromised by comparing the diastolic performance parameter with a specified threshold value; and

wherein the pacing controller is further programmed to adjust one or more rate-adaptive pacing parameters that define the rate-response function if a comparison of the diastolic performance parameter with a specified threshold value indicates diastolic filling is compromised, wherein the one or more rate-adaptive pacing parameter are adjusted in a manner that tends to prevent increases in the modified pacing rate which compromise diastolic filling.

2. The cardiac pacing system of claim 1 wherein the pacing controller is further programmed to adjust one or more rate-adaptive pacing parameters in a manner that maximizes diastolic performance.

3. The cardiac pacing system of claim 1 wherein the rate-adaptive pacing parameter adjusted by the pacing controller is a maximum heart rate.

4. The cardiac pacing system of claim 1 wherein the rate-adaptive pacing parameter adjusted by the pacing controller is a slope of a rate response curve.

5. The cardiac pacing system of claim 1 wherein the rate-adaptive pacing parameter adjusted by the pacing controller results in cessation of rate-adaptive pacing.

6. The cardiac pacing system of claim 1 wherein the diastolic performance sensor comprises a pressure sensor to sense a signal indicative of a left ventricular pressure.

7. The cardiac pacing system of claim 6 wherein the pressure sensor comprises a left ventricular pressure sensor.

8. The cardiac pacing system of claim 6 wherein the pressure sensor comprises a left atrial pressure sensor.

9. The cardiac pacing system of claim 6 wherein the pressure sensor comprises a coronary vein pressure sensor.

10. The cardiac pacing system of claim 6 wherein the pressure sensor comprises a pulmonary arterial pressure sensor.

11. The cardiac pacing system of claim 1 wherein the diastolic performance parameter generator comprises a diastolic pressure detector to detect a left ventricular end diastolic pressure from the signal indicative of the left ventricular pressure.

12. The cardiac pacing system of claim 1 wherein the diastolic performance parameter generator comprises a diastolic pressure detector to detect a pulmonary arterial diastolic pressure from the signal indicative of pulmonary arterial pressure.

13. The cardiac pacing system of claim 1 wherein the diastolic performance parameter generator comprises a diastolic pressure timer to measure a time constant related to a decrease in the left ventricular pressure.

14. The cardiac pacing system of claim 1 wherein the diastolic performance sensor comprises a flow sensor to sense a signal indicative of a blood flow.

15. The cardiac pacing system of claim 14 wherein the flow sensor comprises an impedance sensing circuit.

16. The cardiac pacing system of claim 14 wherein the flow sensor includes a pulmonary blood flow sensor adapted to sense a signal indicative of a pulmonary venous blood flow.

17. The cardiac pacing system of claim 14 wherein the diastolic performance parameter generator comprises a velocity detector to calculate an antegrade pulmonary venous blood velocity based on the signal indicative of the pulmonary venous blood flow.

18. The cardiac pacing system of claim 14 wherein the flow sensor includes a mitral blood flow sensor adapted to sense a signal indicative of a blood flow through a mitral valve.

19. The cardiac pacing system of claim 18 wherein the diastolic performance parameter generator comprises a peak detector to detect a peak blood flow from the signal indicative of the blood flow through the mitral valve.

20. The cardiac pacing system of claim 14 wherein the diastolic performance parameter generator comprises a timer to measure a duration of a rapid initial blood flow from the signal indicative of the blood flow through the mitral valve.

21. The cardiac pacing system of claim 14 wherein the diastolic performance parameter generator comprises a timer to measure a time constant related to a decrease in the blood flow through the mitral valve from the signal indicative of the blood flow through the mitral valve.

22. The cardiac pacing system of claim 14 wherein the diastolic performance parameter generator comprises a timer to measure a ratio of the peak of initial blood flow and late blood flow from the signal indicative of the blood flow through the mitral valve.

23. The cardiac pacing system of claim 1 wherein the diastolic performance sensor comprises a volume sensor indicative of left ventricular volume.

24. The cardiac pacing system of claim 15 wherein the volume sensor comprises an impedance sensing circuit.

25. The cardiac pacing system of claim 23 wherein the diastolic performance parameter generator comprises a peak detector to detect a total change in LV volume during diastole.

26. The cardiac pacing system of claim 1 wherein the diastolic performance sensor comprises an acoustic sensor to sense a signal indicative of heart sounds.

27. The cardiac pacing system of claim 26 wherein the acoustic sensor comprises an accelerometer.

28. The cardiac pacing system of claim 26 wherein the acoustic sensor comprises a microphone.

29. The cardiac pacing system of claim 26 wherein the diastolic performance parameter generator comprises a heart sound analyzer to detect a diastolic acoustic noise from the signal indicative of heart sounds.

30. The cardiac pacing system of claim 1 wherein the pacing controller further programmed to adjust the atrioventricular delay during dual chamber or biventricular pacing in accordance with the diastolic performance parameter.

31. The cardiac pacing system of claim 1 wherein the pacing controller further programmed to adjust the inter-ventricular delay during biventricular pacing in accordance with the diastolic performance parameter.

32. A method for treating a patient with diastolic heart failure, comprising:

implanting a pacing system in the patient;

programming the pacing system to deliver pacing therapy in a rate-adaptive mode wherein a rate-adaptive algorithm maps the exertion level signals to a modified pacing rate in accordance with a rate-response function;

measuring a diastolic performance parameter during heart rate changes brought about by the rate-adaptive pacing therapy, wherein the diastolic performance parameter relates to how optimally the ventricles are filling with blood during diastole;

determining if diastolic filling is compromised by comparing the diastolic performance parameter with a specified threshold value; and

,

adjusting one or more rate-adaptive pacing parameters that define the rate-response function if a comparison of the diastolic performance parameter with a specified threshold value indicates diastolic filling is unduly compromised,

wherein the one or more rate-adaptive pacing parameter are adjusted in a manner that tends to prevent increases in the modified pacing rate which compromise diastolic filling.

33. The method of claim 32 further comprising adjusting one or more rate-adaptive pacing parameters in a manner that maximizes diastolic performance.

34. The method of claim 32 wherein the rate-adaptive pacing parameter is a maximum heart rate.

35. The method of claim 32 wherein the rate-adaptive pacing parameter adjusted is a slope of a rate response curve.