Tissue marking implant

• US 7,871,438 B2
• Filed: 10/23/2009
• Issued: 01/18/2011
• Est. Priority Date: 10/10/1997
• Status: Expired due to Term

• Current Assignee: Senorx Incorporated (Becton, Dickinson & Co)
• Original Assignee: Senorx Incorporated (Becton, Dickinson & Co)
• Inventors: Corbitt, John D. Jr.
• Primary Examiner(s): GHERBI, SUZETTE JAIME J
• Application Number:
  US12/589,413
• Publication Number:
  US 20100121445A1
• Time in Patent Office: 452 Days
• Field of Search: 623 7- 8
• US Class Current: 623/8
• CPC Class Codes: A61B 2090/3908 Soft tissue, e.g. breast tissue
• CPC Class Codes: A61F 2/0059 Cosmetic or alloplastic implants A61F2/10 - A61F2/16, A61F2/28 take precedence
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/12 Mammary prostheses and implants
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

A tissue marking implant includes a matrix material and a dye marker. The implant, which can be formed entirely of bioresorbable material such as a collagen foam, is sized and shaped to replace excised tissue. The implant supports surrounding tissue upon implantation, while allowing for in-growth of fibrous tissue to replace the implant. According to various alternative embodiments, the implant is elastically compressible, or can be formed from self-expanding foam or sponges, and can be implanted through a cannula or by injection, as well as by open procedures. The implant can carry therapeutic and diagnostic substances. The dye marker leaches from the implant such that a surgeon, upon subsequent surgical intervention, visibly recognizes the tissue marked by the dye marker.

Claims

1. A method for marking an intracorporeal cavity from which tissue has been excised, comprising:

providing an implant having a resilient foam or sponge-like matrix material configured to facilitate in-growth of tissue, having a radiopaque marker to facilitate subsequent location of the cavity and configured to occupy the intracorporeal cavity;

providing a delivery cannula having a distal end, a distal discharge opening and an inner lumen extending to and in fluid communication with the distal discharge opening;

placing the implant in the inner lumen of the delivery cannula in a compressed condition;

inserting the delivery cannula into the patient and advancing the delivery cannula therein until the distal discharge opening of the delivery cannula is located within the cavity; and

discharging the implant from the delivery cannula through the distal discharge opening into the cavity wherein the implant expands to at least partially fill the cavity and thereby support the surrounding tissue and allowing for in-growth of fibrous tissue into the foam or sponge-like matrix material.

2. The method of claim 1, wherein the implant has incorporated therein at least one substance selected from the group consisting of a medicinal, therapeutic and diagnostic substances.

3. The method of claim 1, wherein the implant has incorporated therein at least one substance is selected from the group consisting of radiation material, antibiotics, chemotherapies, cancer therapies, hemostatic material, hormone therapies, stem cells and cellular precursors.

4. A method for marking a cavity within a patient'"'"'s breast from which tissue has been removed, comprising:

providing a self-expandable foam implant formed of resorbable material, having a dye marker and being sized to occupy the cavity; and

implanting the implant in the cavity and allowing the implant to expand therein so as to support tissue surrounding the cavity and to allow in-growth of fibrous tissue into and replacing the resorbable material wherein the dye marker leaches into the tissue surrounding the cavity to mark the cavity.

5. The method of claim 4, the implant has incorporated therein at least one substance selected from the group consisting of a medicinal substance, a therapeutic substance and a diagnostic substance.

6. The method of claim 4, wherein the implant has incorporated therein at least one substance selected from the group consisting of radiation material, antibiotics, cancer therapies, hemostatic material, hormone therapies, stem cells, cellular precursors, and radiographic markers.