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Methods and compositions relating to the regulation of apoptosis by MUC1 and BH3-containing proapoptotic proteins

  • US 7,871,784 B2
  • Filed: 02/01/2008
  • Issued: 01/18/2011
  • Est. Priority Date: 02/02/2007
  • Status: Active Grant
First Claim
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1. A method of identifying a compound that inhibits the binding of MUC1 to a BH3-containing proapoptotic protein, the method comprising:

  • (a) contacting a MUC1 reagent comprising the cytoplasmic domain of MUC1 with a MUC1-binding BH3-containing proapoptotic protein or a MUC1-binding fragment thereof in the presence of a candidate compound; and

    (b) determining whether the candidate compound inhibits binding of the MUC1 reagent to the BH3-containing proapoptotic protein or the fragment thereof.

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