System, method, and product for scanning of biological materials
First Claim
1. A probe array cartridge transport assembly apparatus comprising:
- a cartridge magazine, having an open top and an open bottom, capable of holding one or more probe array cartridges, wherein each probe array cartridge comprises at least one barcode, a planar substrate and an array of biological molecules covalently bound to a surface of the substrate;
a cartridge transport assembly comprising a cartridge holder, wherein the cartridge holder comprises at least one motor and a pitch and roll mechanism, and wherein the cartridge transport assembly is capable of transporting a probe array cartridge from the cartridge magazine to a scanner and back to the cartridge magazine and is further capable of advancing the cartridge magazine by one or more positions to a second probe array cartridge;
a barcode reader; and
a scanner.
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Accused Products
Abstract
An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
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Citations
28 Claims
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1. A probe array cartridge transport assembly apparatus comprising:
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a cartridge magazine, having an open top and an open bottom, capable of holding one or more probe array cartridges, wherein each probe array cartridge comprises at least one barcode, a planar substrate and an array of biological molecules covalently bound to a surface of the substrate; a cartridge transport assembly comprising a cartridge holder, wherein the cartridge holder comprises at least one motor and a pitch and roll mechanism, and wherein the cartridge transport assembly is capable of transporting a probe array cartridge from the cartridge magazine to a scanner and back to the cartridge magazine and is further capable of advancing the cartridge magazine by one or more positions to a second probe array cartridge; a barcode reader; and a scanner. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification