Modulating immune responses

• US 7,872,103 B2
• Filed: 02/03/2010
• Issued: 01/18/2011
• Est. Priority Date: 11/21/2001
• Status: Expired due to Fees

• Current Assignee: Celltech R&D Ltd (UCB SA)
• Original Assignee: Celltech R&D Ltd (UCB SA)
• Inventors: Chen, Yuching, Andrews, Dawn, Garcia-Martinez, Leon Fernando
• Primary Examiner(s): Belyavskyi; Michail A
• Application Number:
  US12/699,636
• Publication Number:
  US 20100249380A1
• Time in Patent Office: 349 Days
• Field of Search: None
• US Class Current: 530/387.9
• CPC Class Codes: C07K 16/2803 against the immunoglobulin superfamily
• CPC Class Codes: C07K 2317/50 characterized by immunoglobulin fragments
• CPC Class Codes: C07K 2317/565 Complementarity determining region [CDR]
• CPC Class Codes: C07K 2317/73 Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention provides methods for modulating the immune system using anti-CD83 antibodies that can influence CD83 function.

Claims

1. An isolated multimerized antibody that can bind to a CD83 polypeptide comprising amino acid sequence SEQ ID NO:

97, wherein the multimerized antibody comprises amino acid sequence SEQ ID NO;

70.

2. The antibody designated 96G08 comprising SEQ ID NOs:

70 and 78.

3. An isolated multimerized antibody that can bind to a CD83 polypeptide comprising amino acid sequence SEQ ID NO:

97, where the multimerized antibody comprises amino acid sequence SEQ ID NO;

78.

4. An isolated multimerized antibody that can bind to a CD83 polypeptide comprising amino acid sequence SEQ ID NO:

97, where the multimerized antibody comprises six CDRs of amino acid sequences SEQ ID NO;

71, SEQ ID NO;

72, SEQ ID NO;

73, SEQ ID NO;

77, SEQ ID NO;

80, and SEQ ID NO;

81.