Electro-surgical needle apparatus

• US 7,875,025 B2
• Filed: 02/06/2006
• Issued: 01/25/2011
• Est. Priority Date: 02/04/2005
• Status: Active Grant

• Current Assignee: Instrumedical Limited
• Original Assignee: Instrumedical Limited
• Inventors: Cockburn, Donald James Alexander, Cockburn, John Francis, Wemyss-Holden, Simon
• Primary Examiner(s): Dvorak; Linda C
• Assistant Examiner(s): SCOTT, AMANDA L
• Application Number:
  US11/348,541
• Publication Number:
  US 20060217704A1
• Time in Patent Office: 1,814 Days
• Field of Search: 606/41, 606 32- 34, 606 48- 50, 607101-102, 607115-116, 340635-63616, 340660-663
• US Class Current: 606/41
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 2018/0016 Energy applicators arranged in a two- or three dimensional array
• CPC Class Codes: A61B 2018/1407 Loop
• CPC Class Codes: A61B 2018/1467 using more than two electrodes on a single probe
• CPC Class Codes: A61B 2018/1475 Electrodes retractable in or deployable from a housing
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61B 8/0841 for locating instruments
• CPC Class Codes: A61B 8/488 involving Doppler signals

Abstract

A needle assembly (N) for RF ablation of target tissue in e.g. the liver (L) of a patient comprises a radial array of electrodes (1) in the form of loops which can be expanded by feeding the proximal ends of the Y electrodes along the bore of the needle assembly. An RF power supply (2) is connection between the array of electrodes and a skin pad (P) in contact with the skin (S) of a patient and, in accordance with the invention, is biased by a DC power supply 4 which generates electro-osmotic and/or electrolytic effects in the target tissue. In particular, chloride ions are discharged to generate chlorine which has a potent cytocidal effect and water can be attracted to the array of electrodes by electro-osmosis, thereby alleviating the problems of low electrical and thermal conductivity encountered with conventional apparatus.

Claims

1. Surgical apparatus for treating tumours in internal organs or bones of a human patient, the apparatus comprising a penetrative needle assembly for penetrating into an internal organ or bone of the human patient and ablating tumour tissue therein, said penetrative needle assembly comprising at least one cathode in an ablation zone of the needle assembly for hydrating, by electro-endosmosis, target tumour tissue in the ablation zone, an AC source coupled to the penetrative needle assembly for supplying ablating power of at least 5 W thereto, a DC source for biasing said cathode to a negative potential to induce said electro-endosmosis, wherein said AC source and said DC source are provided with switching means for inducing said electro-endosmosis prior to or simultaneously with ablating said tumour tissue in the ablation zone.

2. Surgical apparatus according to claim 1, wherein said apparatus further comprises means for establishing an electrical connection of positive polarity with the body of the patient.

3. Surgical apparatus according to claim 1, further comprising an anode for insertion into the patient'"'"'s body tissue.

4. Surgical apparatus according to claim 1, wherein said anode is in the form of a needle.

5. Surgical apparatus according to claim 1, wherein said negative potential is in the range −

9V to −

12V relative to a positive pole of said DC source.

6. Surgical apparatus according to claim 1, comprising means for applying an initial treatment phase in which said cathode is biased to a negative potential to induce electro-endosmosis and for applying a subsequent treatment phase in which said energy transfer means is activated to ablate target tumour tissue hydrated in the initial treatment phase.

7. Surgical apparatus according to claim 1, wherein said needle assembly comprises a cannula and at least one said cathode disposed within and extendable from a distal end of said cannula and shaped to penetrate into target tissue.

8. Surgical apparatus according to claim 1, wherein a plurality of electrodes for inducing electro-endosmosis in target tumour tissue in said region are disposed within and extendable from the distal end of said cannula.

9. Surgical apparatus according to claim 1, wherein said penetrative needle assembly comprises a plurality of electrodes, wherein all said electrodes are biased with negative polarity.

10. Surgical apparatus according to claim 1, wherein said needle assembly has a lumen communicating with a source of conducting liquid or cytocidal substance or precursor thereof for introducing the conducting liquid or substance into said target tumour tissue, said cathode being in electrical contact with said conducting liquid or substance for inducing electro-endosmosis in target tissue in said zone.

11. Surgical apparatus according to claim 10, wherein said needle arrangement has a further lumen and further comprising extraction means in communication with said further lumen for extracting liquid, solid or gaseous debris from said target tissue.

12. Surgical apparatus according to claim 1, which includes means for generating electrolysis in said zone.

13. Surgical apparatus according to claim 12, wherein said apparatus further comprises ultrasonic imaging means for detecting electrolytically-produced gases in said zone.

14. Surgical apparatus according to claim 13, wherein said ultrasonic imaging means is a Doppler ultrasound imager.

15. Surgical apparatus according to claim 1, wherein said needle assembly comprises an extendable electrode array enclosing a volume of tumour tissue for selective ablation of a periphery of said volume of tumour tissue.

16. Surgical apparatus according to claim 1, wherein said AC source is an RF ablation power supply.

17. A method of treatment of a tumour in an organ or bone of a human or an animal body, the method comprising (a) providing the surgical apparatus of claim 1;

and (b) applying the apparatus to the human or animal body to induce electro-endosmosis in and hydrate target tumour tissue of the human or animal body in the ablation zone and subsequently or simultaneously to ablate the target tumour tissue in the ablation zone.

18. A method according to claim 17, wherein the electro-endosmosis is induced prior to ablating the target tumour tissue.

19. A method according to claim 17, wherein the electro-endosmosis is induced for a period of 60 to 600 seconds prior to ablating the target tumour tissue.

20. A method according to claim 17, wherein the electro-endosmosis is induced for a period of 120 to 400 seconds prior to ablating the target tumour tissue.

21. A method according to claim 17, wherein the electro-endosmosis is induced for a period of 240 to 360 seconds prior to ablating the target tumour tissue.

22. A method according to claim 17 wherein the electro-endosmosis is induced by applying a DC potential between an external conductive pad and the cathode of the penetrative needle assembly, the external conductive pad being in contact with the skin of the human or animal body.

23. A method according to claim 17 wherein the electro-endosmosis is induced by applying a DC potential between an anodic electrode and the cathode of the penetrative needle assembly, the anodic electrode being inserted into the human or animal body and being spaced apart from the penetrative needle assembly.

24. A method according to claim 17 wherein said needle assembly comprises an extended electrode array enclosing a volume of tumour tissue and a periphery of said volume is ablated.

25. A method according to claim 17 wherein said organ is a liver.

26. A method according to claim 17 wherein a negative DC potential sufficient to generate gas bubbles by electrolysis is applied to said penetrative needle assembly and said gas bubbles are detected by ultrasonic imaging.

27. A method according to claim 17 wherein said target tumour tissue is ablated with a power of at least 5 W.

28. A method according to claim 17 wherein said target tumour tissue is ablated with a power of at least 10 W.

29. A method according to claim 17 wherein said target tumour tissue is ablated with a power of at least 20 W.