Generalized pulse jet ejection head control model

• US 7,875,463 B2
• Filed: 03/26/2004
• Issued: 01/25/2011
• Est. Priority Date: 03/26/2004
• Status: Active Grant

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Agilent Technologies, Inc.
• Inventors: Peck, Bill J., Adaskin, David R., Chesk, William G., Woods, Stanley P.
• Primary Examiner(s): Gordon; Brian R
• Application Number:
  US10/809,981
• Publication Number:
  US 20050214775A1
• Time in Patent Office: 2,496 Days
• Field of Search: 422/100, 422 63- 681, 436/43, 436/180, 436/49, 700/17, 700/32, 700/52, 700/57, 700/65, 700/241, 700/266, 700/283
• US Class Current: 436/180
• CPC Class Codes: B01J 19/0046 Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays synthesis methods per se C40B50/00
• CPC Class Codes: B01J 2219/00378 Piezoelectric or ink jet dispensers
• CPC Class Codes: B01J 2219/00527 Sheets
• CPC Class Codes: B01J 2219/00576 fluorophore
• CPC Class Codes: B01J 2219/00585 Parallel processes
• CPC Class Codes: B01J 2219/00596 Solid-phase processes
• CPC Class Codes: B01J 2219/00605 the compounds being directly bound or immobilised to solid supports
• CPC Class Codes: B01J 2219/0061 The surface being organic
• CPC Class Codes: B01J 2219/00612 the surface being inorganic
• CPC Class Codes: B01J 2219/00626 Covalent
• CPC Class Codes: B01J 2219/00659 Two-dimensional arrays
• CPC Class Codes: B01J 2219/00675 In-situ synthesis on the substrate
• CPC Class Codes: B01J 2219/00677 Ex-situ synthesis followed by deposition on the substrate
• CPC Class Codes: B01J 2219/00689 using computers
• CPC Class Codes: B01J 2219/00691 using robots
• CPC Class Codes: B01J 2219/00693 Means for quality control
• CPC Class Codes: B01J 2219/00695 Synthesis control routines, e.g. using computer programs
• CPC Class Codes: B01J 2219/00722 Nucleotides
• CPC Class Codes: B01J 2219/00725 Peptides
• CPC Class Codes: B01J 2219/00729 Peptide nucleic acids [PNA]
• CPC Class Codes: B01J 2219/00731 : Saccharides
• CPC Class Codes: B82Y 30/00 : Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: Y10T 436/11 : Automated chemical analysis
• CPC Class Codes: Y10T 436/114998 : with treatment or replacement of aspirator element [e.g., cleaning, etc.]
• CPC Class Codes: Y10T 436/2575 : Volumetric liquid transfer

Abstract

A generalized printhead control model is provided herein as a basis for configuring printhead control software that will operate any selected printhead or group of printheads. The subject model covers a hierarchy of classes for the attributes of software that controls the printheads in a system, such as for producing a biopolymer array.

Claims

1. A method for preparing a biopolymer array production system for operation, the method comprising:

providing a biopolymer array production system comprising;

a substrate station configured to retain a biopolymer array substrate;

a movable printhead system comprising a first printhead assembly; and

a computer processor configured to control said movable printhead system to form a biopolymer array on a substrate retained in said substrate station;

replacing said first printhead assembly with a second printhead assembly, wherein said first and second printhead assemblies are different and wherein said second printhead assembly comprises multiple printheads, wherein each of said printheads comprises a nozzle plate, one or more wells, wherein each of said one or more wells comprises one or more nozzle regions, wherein each of said one or more nozzle regions comprises one or more nozzle rows and wherein each of said one or more nozzle rows comprises multiple nozzle orifices;

entering, by an operator using an operator input device or electronically reading from electronic media, printhead-related data into said computer processor, wherein printhead-related data includes one or more of;

the type of each of said printheads, number of said printheads of said printhead assembly, type of nozzle plate on each of said printheads, alignment method of said nozzle plate, number of wells per each of said printheads, number of nozzle orifices per well, number of nozzle rows per each of said printheads, spacing between said nozzle orifices, and spacing between said nozzle rows,

wherein said type of each of said printheads is selected from a piezo-based printhead, a thermal-based printhead or a resistance-based printhead; and

configuring, with said computer processor, a printhead control routine based on said entered data, in order to control printhead function.

2. The method of claim 1, wherein a user interface prompts user entry of at least one of said criteria.

3. The method of claim 2, wherein a user enters at least one of said criteria.

4. The method of claim 1 wherein said type of printheads, number of said printheads, type of nozzle plate and alignment method are Printhead Assembly Objects, and said number of wells per each of said printheads, number of nozzle orifices per each of said wells, number of nozzle rows per each of said printheads, spacing between nozzle orifices and spacing between nozzle rows are Printhead Group Objects, as treated by said processor.

5. The method of claim 4, wherein, when one or more data selected from Printhead Assembly Objects is entered and one or more data selected from Printhead Group Objects is entered, said processor first configures a portion of said control routine based on said entered data from Printhead Assembly Objects, then configures another portion of said control routine based on said entered data from Printhead Group Objects in relation to said entered data from Printhead Assembly Objects.

9. A method of producing a biopolymer array, the method comprising:

providing a production system prepared according to the method of any of claims 1 through 7, and

controlling said system by said control routine to print a biopolymer array by ejecting reagent drops from any of said printheads spaced from a substrate surface during movement of said printheads and said surface relative to each other,

wherein said reagent drops are ejected according to a predetermined pattern onto said surface to produce said array.

10. The method of claim 9, wherein said biopolymers are polyncucleotides or polypeptides.

11. A method of detecting the presence of an analyte in a sample, said method comprising:

producing a biopolymer array according to the method of claim 9;

contacting a sample suspected of comprising said analyte with said biopolymer array; and

detecting any binding complexes on the surface of said biopolymer array to obtain binding complex data.

12. The method of claim 11, wherein said analyte is a nucleic acid.

13. A method comprising transmitting data resulting from a detecting according to claim 11, from a first location to a remote location.

14. A method comprising receiving data representing a result of a reading obtained by the method of claim 11.

15. A method comprising forwarding data representing a result of a reading an array fabricated by the method of claim 11.

16. A computer-readable medium comprising a program as configured by the method of claim 1 to direct an array fabrication apparatus.

17. A kit comprising the computer readable medium of claim 16, in packaged combination with instructions for use with an array fabrication apparatus.

18. The method of claim 1, wherein said printhead assemblies comprise multiple printhead groups comprising one or more printheads, each of said printhead groups capable of printing a complete set of fluids to be dispensed by said printhead assembly.

19. The method of claim 1, wherein said entering step comprises entering printhead-related data including criteria for both the type of each of said printheads and alignment method of said nozzle plate.

20. The method of claim 1, wherein said entering step comprises entering printhead-related data including criteria for both the number of said printheads of said second printhead assembly and alignment method of said nozzle plate.

21. The method of claim 1, wherein said entering step comprises entering printhead-related data including criteria for both the number of nozzle rows per each of said printheads and the spacing between said nozzle rows.

22. The method of claim 1, wherein said entering step comprises entering printhead-related data comprising all of said criteria.

6. A method for preparing a biopolymer array production system for operation, the method comprising:

providing a biopolymer array production system comprising;

a substrate station configured to retain a biopolymer array substrate;

a movable printhead system comprising a first printhead assembly; and

a computer processor configured to control said movable printhead system to form a biopolymer array on a substrate retained in said substrate station;

replacing said first printhead assembly with a second printhead assembly, wherein said first and second printhead assemblies are different and wherein said second printhead assembly comprises multiple printheads, wherein each of said printheads comprises a nozzle plate, one or more wells, wherein each of said one or more wells comprises one or more nozzle regions, wherein each of said one or more nozzle regions comprises one or more nozzle rows and wherein each of said one or more nozzle rows comprises multiple nozzle orifices;

providing printhead-related data into said computer processor, wherein said printhead-related data includes Printhead Assembly Object criteria and Printhead Group Object criteria, said Printhead Assembly Object criteria selected from the type of each of said printheads, number of said printheads of said printhead assembly, type of nozzle plate on each of said printheads and alignment method of said nozzle plate, said Printhead Group Object criteria selected from a number of wells per each of said printheads, number of nozzle orifices per well, number of nozzle rows per each of said printheads, spacing between said nozzle orifices and spacing between said nozzle rows, wherein said type of each of said printheads is selected from a piezo-based printhead, a thermal-based printhead or a resistance-based printhead; and

configuring, with said computer processor, a printhead control routine based on said data by first producing a portion of said control routine based on said Printhead Assembly Objects, then producing another portion of said routine based on said Printhead Group Objects in relation to said Printhead Assembly Objects.

7. The method of claim 6, wherein an operator enters information corresponding to at least a portion of said printhead-related data.

8. The method of claim 6, wherein said printhead-related data is provided from electronic media associated with said second printhead assembly.