Selective serotonin receptor inverse agonists as therapeutics for disease

• US 7,875,632 B2
• Filed: 02/11/2009
• Issued: 01/25/2011
• Est. Priority Date: 05/21/2004
• Status: Active Grant

• Current Assignee: Acadia Pharmaceuticals Inc.
• Original Assignee: Acadia Pharmaceuticals Inc.
• Inventors: Davis, Robert E., Brann, Mark R., Weiner, David M.
• Primary Examiner(s): Padmanabhan; Sreeni
• Assistant Examiner(s): Javanmard; Sahar
• Application Number:
  US12/378,385
• Publication Number:
  US 20090155389A1
• Time in Patent Office: 713 Days
• Field of Search: 514/217, 514/317, 514/469, 514/722, 514/378, 514/618, 514/225, 514/277, 514/225.5, 514/588, 514/595
• US Class Current: 514/317
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/138 Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine atenolol A61K31/165; pindolol A61K31/404; timolol A61K31/5377
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 31/4468 having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/14 for treating abnormal movements, e.g. chorea, dyskinesia
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 25/36 Opioid-abuse
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Disclosed herein are pharmaceutical compositions comprising an inverse serotonin receptor agonist or a serotonin receptor antagonist and an anti-psychotic agent. Disclosed herein are also methods of treating psychotic disorders using the disclosed pharmaceutical compositions.

Claims

1. A pharmaceutical composition comprising:

a first compound of Formula (I)

2. The pharmaceutical composition of claim 1 wherein the MAO-I is selected from the group consisting of tranylcypromine (Parnate), phenelzine (Nardil), maprotiline, and isocarboxazid (Marplan).

3. The pharmaceutical composition of claim 1, further comprising a physiologically acceptable carrier, diluent, or excipient, or a combination thereof.

4. The composition of claim 1, wherein the compound of formula (I) is the free base.

5. The composition of claim 1, wherein the composition is in a single unit dosage form.

6. The composition of claim 5, wherein the composition is in a single unit dosage fowl suitable for oral administration to a human.

7. The composition of claim 6, wherein the dosage form is solid.

8. The composition of claim 7, wherein the composition is in the form of a tablet or a capsule.

9. The composition of claim 8, wherein the composition is in the form of a tablet.

10. The composition of claim 1, wherein the amount of the compound of formula (I), or a pharmaceutically acceptable salt thereof, is from about 0.1 mg to about 500 mg.

11. The composition of claim 1, wherein the amount of the compound of formula (I), or a pharmaceutically acceptable salt thereof, is from about 1 mg to about 40 mg.