Computer instructions for guiding differential diagnosis through information maximization
First Claim
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1. In a non-transitory computer readable storage medium having stored therein data representing instructions executable by a programmed processor for determining at least one question of interest, the storage medium comprising instructions for:
- providing patient observations including patient medical data;
providing clinical observations based on recorded clinical data;
identifying mutual information between the question of interest and the recorded clinical data by comparing the patient observations with the clinical observations to determine dependence between the question of interest and the recorded clinical data as it relates to the patient observations, wherein the dependence between the question of interest and the recorded clinical data indicates the mutual information;
selecting relevant observation data by maximizing the dependence between the recorded clinical data about the question of interest given the patient medical data, wherein the relevant observation data is unknown with respect to the patient but is relevant for analyzing the at least one question of interest based on the identification of the mutual informationdetermining a solution for the at least one question of interest that comprises a result derived from the relevant observation data, wherein the solution comprises a determination of the unknown from the relevant observation data such that the unknown with respect to the patient is known based on the result;
obtaining additional observations based on the determined solution, wherein the additional observations comprise results of an implementation of the determined solution; and
iteratively repeating the comparing, selecting, and determining after updating the patient medical data with the additional observations, wherein each iteration utilizes updated patient medical data that includes the additional observations from a previous iteration.
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Abstract
A system and method for diagnosis and treatment decisions based on information maximization is disclosed. Utilizing patient information as well as clinical records from other patients can reduce the uncertainty in both diagnosis and treatment options. The information maximization may consider additional data such as risk, cost, and comfort in making a proper medical decision.
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Citations
23 Claims
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1. In a non-transitory computer readable storage medium having stored therein data representing instructions executable by a programmed processor for determining at least one question of interest, the storage medium comprising instructions for:
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providing patient observations including patient medical data; providing clinical observations based on recorded clinical data; identifying mutual information between the question of interest and the recorded clinical data by comparing the patient observations with the clinical observations to determine dependence between the question of interest and the recorded clinical data as it relates to the patient observations, wherein the dependence between the question of interest and the recorded clinical data indicates the mutual information; selecting relevant observation data by maximizing the dependence between the recorded clinical data about the question of interest given the patient medical data, wherein the relevant observation data is unknown with respect to the patient but is relevant for analyzing the at least one question of interest based on the identification of the mutual information determining a solution for the at least one question of interest that comprises a result derived from the relevant observation data, wherein the solution comprises a determination of the unknown from the relevant observation data such that the unknown with respect to the patient is known based on the result; obtaining additional observations based on the determined solution, wherein the additional observations comprise results of an implementation of the determined solution; and iteratively repeating the comparing, selecting, and determining after updating the patient medical data with the additional observations, wherein each iteration utilizes updated patient medical data that includes the additional observations from a previous iteration. - View Dependent Claims (2, 3, 4, 5)
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6. In a non-transitory computer readable storage medium having stored therein data representing instructions executable by a programmed processor for making a medical decision regarding a particular patient and a medical question of interest, the storage medium comprising instructions for:
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receiving patient information comprising data related to the particular patient; receiving clinical data from pre-existing medical records, wherein the clinical data comprises data from a plurality of other patients; determining, from the clinical data, mutual information between the medical question of interest and the clinical data based on a comparison of the patient information with clinical data from a subset of patients with similar conditions as the particular patient, wherein the mutual information comprises an unknown variable for the particular patient, but comprises a known variable from at least one of the plurality of other patients, further wherein the unknown variable assists with identifying the medical decision; selecting relevant observation data by maximizing a dependence between the unknown variable for the particular patient and the known variable from at least one of the plurality of other patients in view of the patient information, wherein the relevant observation data is relevant for analyzing the medical question of interest based on the determination of the mutual information; utilizing the relevant observation data for identifying the medical decision, wherein the medical decision comprises uncovering the unknown variable for the particular patient such that the patient information is updated to include results for the medical decision and the unknown variable becomes known based on the results; obtaining additional observations based on the identified medical decision, wherein the additional observations comprise results of an implementation of the identified medical decision; and iteratively repeating the determination, selection and utilization with the updated patient information, wherein the identified results for the medical decision are updated based on a previous iteration'"'"'s results. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A computing system for reducing uncertainty of a medical condition for a particular patient, the system comprising:
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a source of patient data, wherein the patient data comprises medical data from a patient history for the particular patient; a source of clinical data, wherein the clinical data comprises a collection of patient data from other patients; a memory coupled with the patient data source and the clinical data source that receives and stores the patient data and the clinical data; a processor coupled with the memory and configured for; identifying mutual information between the medical condition and the clinical data by comparing the clinical data from a subset of patients with similar conditions to the particular patient with the patient data, wherein the comparison determines a dependence between the medical condition and the clinical data as it relates to the patient data, wherein the dependence between the medical condition and the clinical data indicates the mutual information; determining relevant clinical data with a maximization of the dependence between the medical condition and the clinical data in view of the patient data, wherein the relevant clinical data is unknown with respect to the particular patient, but is relevant for analyzing the medical condition of the particular patient based on the identification of the mutual information; analyzing the relevant clinical data to determine a medical decision for the medical condition, wherein the medical decision comprises a determination of the unknown from the relevant clinical data with respect to the particular patient, such that the unknown with respect to the particular patient is known based on the medical decision; updating the patient data based on the determined medical decision; and repeating the comparing, determining, and analyzing, wherein the repeating comprises utilizing the updated patient data; and a display coupled with the processor that provides the medical decision. - View Dependent Claims (18, 19, 20, 21, 22, 23)
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Specification