Controlled release devices for fusion of osteal structures

• US 7,879,027 B2
• Filed: 09/08/2006
• Issued: 02/01/2011
• Est. Priority Date: 04/24/2006
• Status: Active Grant

• Current Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Original Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Inventors: Trieu, Hai H.
• Primary Examiner(s): Sirmons; Kevin C
• Assistant Examiner(s): Mehta; Bhisma
• Application Number:
  US11/517,771
• Publication Number:
  US 20070276337A1
• Time in Patent Office: 1,607 Days
• Field of Search: 604/891.1, 604/892.1, 604/65, 604/66, 604/67, 623/17.11, 623/17.12, 623/17.13, 623/17.15, 623/17.16
• US Class Current: 604/892.1
• CPC Class Codes: A61B 17/58 for osteosynthesis, e.g. bone plates, screws , setting implements or the like A61B17/14, A61B17/16 take precedence
• CPC Class Codes: A61B 17/7061 for stabilising vertebrae or discs by improving the condition of their tissues, e.g. using implanted medication or fluid exchange intraosseous injection devices A61B17/3472
• CPC Class Codes: A61B 17/7097 Stabilisers comprising fluid filler in an implant, e.g. balloon; devices for inserting or filling such implants disc prostheses made of inflatable chambers or pockets filled with fluid A61F2/441; replacing the nucleus pulposus A61F2002/444
• CPC Class Codes: A61B 17/8858 laterally or radially expansible inflatable A61B17/8855
• CPC Class Codes: A61B 2017/00557 inflatable A61B2017/22051 takes precedence
• CPC Class Codes: A61B 2017/0256 for the spine
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/3068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 2210/02 Bones
• CPC Class Codes: A61M 2210/1003 Spinal column
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407

Abstract

A device includes a first reservoir configured to include a degradation agent, a first control element configured to provide access to the first reservoir, and an expandable component configured to extend to engage an osteal structure.

Claims

1. A device comprising:

a first reservoir configured to include an osteogenerative agent;

a second reservoir configured to include a degradation agent;

a first valve in fluid communication with the first reservoir, wherein the first valve is configured to open in response to a first soft tissue condition of pressure or hydration and close in response to a second soft tissue condition;

a second valve in fluid communication with the second reservoir, wherein the second valve is configured to remain closed during the first soft tissue condition and the second soft tissue condition and is configured to open in response to a third soft tissue condition; and

an osmotic driver coupled to the first reservoir and the second reservoir.

2. The device of claim 1, wherein the second valve is configured to open upon implantation.

3. The device of claim 1, wherein the first soft tissue condition is a low pressure or hydration condition.

4. The device of claim 1, wherein the second soft tissue condition is a pressure or hydration condition higher that the first soft tissue condition.

5. The device of claim 1, wherein the third soft tissue condition is a pressure or hydration condition higher than the first soft tissue condition and the second soft tissue condition.

6. The device of claim 1, wherein the osteogenerative agent includes an osteoconductive agent.

7. The device of claim 1, wherein the osteogenerative agent includes an osteoinductive agent.

8. The device of claim 7, wherein the osteoinductive agent includes bone morphogenetic protein, demineralized bone matrix, transforming growth factor (TGF), osteoblast cells, growth and differentiation factor (GDF), LIM mineralized protein (LMP), platelet derived growth factor (PDGF), insulin-like growth factor (ILGF), or any combination thereof.

9. The device of claim 1, wherein the degradation agent includes chymopapain, collagenase, chondroitinase, keratanase, human proteolytic enzymes, papaya proteinase, or any combination thereof.