Osmotic delivery systems and piston assemblies for use therein
First Claim
1. A piston assembly for positioning in a lumen of a reservoir for an osmotic delivery system, comprisinga columnar body constructed and arranged for positioning in the lumen, wherein the columnar body has a core made of a polymeric material comprising an ultra high molecular weight polyethylene, the columnar body further comprising a rim at a distal end thereof for engaging and sealing against an interior wall of the reservoir and a spring retained at the distal end for biasing the rim against the interior wall of the reservoir.
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Accused Products
Abstract
An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.
139 Citations
16 Claims
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1. A piston assembly for positioning in a lumen of a reservoir for an osmotic delivery system, comprising
a columnar body constructed and arranged for positioning in the lumen, wherein the columnar body has a core made of a polymeric material comprising an ultra high molecular weight polyethylene, the columnar body further comprising a rim at a distal end thereof for engaging and sealing against an interior wall of the reservoir and a spring retained at the distal end for biasing the rim against the interior wall of the reservoir.
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14. An osmotic delivery system for delivering an active agent formulation to a fluid environment, comprising:
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a reservoir, comprising an interior wall, that defines a lumen containing the active agent formulation and an osmotic agent formulation; the active agent formulation comprising a suspension vehicle, the suspension vehicle comprising benzyl benzoate and polyvinylpyrrolidone, and a particle formulation comprising an insulinotropic polypeptide; a piston assembly positioned in the lumen of the reservoir, the piston assembly comprising a columnar body having a core made of a polymeric material comprising an ultra high molecular weight polyethylene, the columnar body further comprising a rim at a distal end thereof for engaging and sealing against the interior wall of the reservoir and a spring retained at the distal end for biasing the rim against the interior wall of the reservoir, wherein the piston assembly isolates the active agent formulation from the osmotic agent formulation; a semipermeable membrane positioned at a first end of the reservoir adjacent the osmotic agent formulation; and a flow modulator positioned at a second end of the reservoir adjacent the active agent formulation, said flow modulator having an orifice for delivering the active agent formulation to the fluid environment.
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Specification