Multipolar, virtual-electrode catheter with at least one surface electrode and method for ablation

• US 7,879,030 B2
• Filed: 07/27/2005
• Issued: 02/01/2011
• Est. Priority Date: 07/27/2005
• Status: Active Grant

• Current Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc. (Abbott Laboratories)
• Original Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc. (Abbott Laboratories)
• Inventors: Belhe, Kedar Ravindra, Paul, Saurav
• Primary Examiner(s): Cohen; Lee S
• Application Number:
  US11/190,560
• Publication Number:
  US 20070027448A1
• Time in Patent Office: 2,015 Days
• Field of Search: 606/41, 606/32, 606/34, 607/105
• US Class Current: 606/41
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2018/1472 for use with liquid electrolyte, e.g. virtual electrodes

Abstract

Virtual-electrode catheters and methods for using such virtual-electrode catheters are disclosed. For example, bipolar and multipolar, virtual-electrode catheters having at least one internal electrode and at least one surface electrode, and methods of using these catheters for treatment of cardiac arrhythmias via, for example, radiofrequency (RF) ablation are disclosed. The catheters may comprise a catheter body with an internal lumen extending within it and adapted to flowingly receive a conductive fluid. An exit feature defining a flow path from the internal lumen to the catheter'"'"'s outer surface may exist through a sidewall of the catheter body. A conductor is mounted within the internal lumen adjacent to the exit feature and is adapted to deliver treatment energy to the tissue via the conductive fluid in the internal lumen. At least one surface electrode is mounted on the outer surface of the catheter body adjacent to the exit feature.

Claims

1. A virtual-electrode catheter for treatment of tissue, the catheter comprising:

a catheter body comprising a sidewall and an outer surface;

a first internal lumen extending within said catheter body and adapted to flowingly receive a conductive fluid;

an exit feature comprising a flow path from said first internal lumen through said catheter body sidewall and said outer surface, said exit feature being adapted to permit the conductive fluid to exit from said first internal lumen toward the tissue;

an internal flexible conductor mounted within said first internal lumen adjacent to said exit feature and an inner surface of said catheter body sidewall, wherein said internal flexible conductor is adapted to deliver treatment energy to the tissue via the conductive fluid in said first internal lumen, wherein said internal flexible conductor is configured to be connected to an energy source to supply the treatment energy; and

at least one surface electrode mounted on said outer surface of said catheter body adjacent to said exit feature, wherein the at least one surface electrode is configured to be connected to a return end of the energy source, wherein the internal flexible conductor operates as an active electrode when connected to the energy source, wherein the at least one surface electrode operates as an inactive return electrode to capture and return at least a portion of the treatment energy to the energy source when the at least one surface electrode is connected to the return end of the energy source, thereby creating an electric field between the internal flexible conductor and the at least one surface electrode, and wherein said at least one surface electrode comprises;

a first surface electrode comprising a first conductive coil along a first side of a longitudinal centerline of said exit feature; and

a second surface electrode comprising a second conductive coil along a second side of said longitudinal centerline of said exit feature;

wherein said first conductive coil and said second conductive coil straddle said exit feature longitudinal centerline.

2. The virtual-electrode catheter of claim 1, wherein said exit feature is selected from the group consisting of a plurality of exit portholes, at least one exit slot, and a plurality of micro-pores.

3. The virtual-electrode catheter of claim 2, wherein said exit feature comprises a plurality of exit portholes arranged along said outer surface of said catheter body.

4. The virtual-electrode catheter of claim 3, wherein said exit feature longitudinal centerline comprises a porthole centerline, and wherein said plurality of exit portholes are symmetrically distributed about said porthole centerline.

5. The virtual-electrode catheter of claim 4, wherein said internal flexible conductor comprises an internal coil electrode, and wherein said internal coil electrode extends adjacent to each exit porthole of said plurality of exit portholes.

6. The virtual-electrode catheter of claim 5, wherein said internal coil electrode comprises a multitude of turns;

wherein said multitude of turns of said internal coil electrode are adapted to allow the conductive fluid to pass between adjacent turns; and

wherein at least two of said multitude of turns of said internal coil electrode are present between adjacent portholes of said plurality of exit portholes.

7. The virtual-electrode catheter of claim 4, wherein said porthole centerline extends longitudinally along said outer surface of said catheter body.

8. The virtual-electrode catheter of claim 2, wherein said exit feature comprises an exit slot extending longitudinally along said outer surface of said catheter body.

9. The virtual-electrode catheter of claim 8, wherein said internal flexible conductor comprises an internal coil electrode, and wherein said internal coil electrode extends over an entire length of said exit slot.

10. The virtual-electrode catheter of claim 1, wherein said internal flexible conductor comprises an internal coil electrode having a multitude of turns;

and wherein said multitude of turns of said internal coil electrode are adapted to allow the conductive fluid to pass between adjacent turns.

11. The virtual-electrode catheter of claim 1, wherein said internal flexible conductor is selected from the group consisting of a coil electrode, a wire strand electrode, and a tubular electrode.

12. The virtual-electrode catheter of claim 11, wherein said internal flexible conductor is constructed from metal.

13. The virtual-electrode catheter of claim 11, wherein said internal flexible conductor comprises a coil electrode having an annular cross-sectional shape, wherein said first internal lumen has an elliptical cross-sectional shape, wherein said coil electrode extends longitudinally within said first internal lumen, and wherein a minor axis of said elliptical cross-sectional shape of said first internal lumen is substantially the same length as an outside diameter of said annular cross-sectional shape of said coil electrode.

14. The virtual-electrode catheter of claim 13, wherein a lateral cross section of said coil electrode and said first internal lumen defines a flow channel comprising a circular central region, a forward crescent-moon-shaped region, and a rearward crescent-moon-shaped region.

15. The virtual-electrode catheter of claim 1, wherein said internal flexible conductor comprises an internal coil electrode having a multitude of turns, wherein said internal coil electrode extends longitudinally within said first internal lumen, and wherein said internal coil electrode is at least partially embedded in a longitudinally-extending internal sidewall of said first internal lumen.

16. The virtual-electrode catheter of claim 1, wherein said surface electrode is constructed from metal.

17. The virtual-electrode catheter of claim 1, wherein said at least one surface electrode is mounted in and retained by a longitudinally-extending, C-shaped channel on said outer surface of said catheter body.

18. The virtual-electrode catheter of claim 1, wherein said first conductive coil is thermally and electrically conductive, and wherein said catheter further comprises a thermal sensor within said first conductive coil.

19. The virtual-electrode catheter of claim 1, wherein said at least one surface electrode is a cooled electrode.

20. The virtual-electrode catheter of claim 19, wherein said at least one surface electrode comprises a coil of wound, tubular metal adapted to carry a cooling fluid.

21. The virtual-electrode catheter of claim 1, wherein said at least one surface electrode acts as a dispersive electrode.

22. The virtual-electrode catheter of claim 1, wherein said first conductive coil is thermally and electrically conductive, and wherein said catheter further comprises a longitudinally-extending thermal sensor that extends within said first conductive coil.

23. The virtual-electrode catheter of claim 1, wherein said catheter further comprises at least one temperature sensor on said outer surface of said catheter body next to said at least one surface electrode.

24. The virtual-electrode catheter of claim 23, wherein said at least one temperature sensor is selected from the group consisting of a thermocouple, a thermister, and a fiber optic sensor.

25. The virtual-electrode catheter of claim 1, wherein said at least one surface electrode is metal, and wherein said internal flexible conductor is metal.

26. The virtual-electrode catheter of claim 1, wherein said virtual-electrode catheter further comprises a terminal sphere, and wherein said internal flexible conductor comprises a distal projection that is anchored to said terminal sphere.

27. The virtual-electrode catheter of claim 26, wherein said virtual-electrode catheter further comprises a release hole that extends from said first internal lumen through said terminal sphere and through said outer surface of said catheter body, and wherein said release hole is adapted to inhibit stagnation of said conductive fluid.

28. The virtual-electrode catheter of claim 1, wherein said catheter body defines a second longitudinally-extending internal lumen adapted to slippingly receive a rail.

29. The virtual-electrode catheter of claim 28, wherein said rail comprises a nickel-titanium wire.

30. The virtual-electrode catheter of claim 28, wherein said rail has a rounded-rectangular cross-sectional configuration that complements a cross-sectional configuration of said second lumen.

31. The virtual-electrode catheter of claim 1, wherein said internal flexible conductor has a tight spring pitch with individual coils that are closely packed

32. The virtual-electrode catheter of claim 31, wherein the individual coils regulate fluid flow within the first internal lumen and out of the exit feature.

33. The virtual-electrode catheter of claim 31, wherein the individual coils stretch and relax under tension and compression to affect fluid flow as a distal portion virtual-electrode catheter is manipulated during use.

34. The virtual-electrode catheter of claim 31, wherein gaps between adjacent individual coils change in size slightly to create pressure gradients in flow distribution along the exit features.

35. The virtual-electrode catheter of claim 31, wherein gaps between adjacent individual coils change in size slightly to affect impedance and heating of the conductive fluid.

36. The virtual-electrode catheter of claim 1, wherein said internal flexible conductor comprises turns which form a hollow portion along a center axis of the internal flexible conductor.

37. A virtual-electrode catheter for tissue ablation, the catheter comprising:

a catheter body having an outer surface, an internal lumen, and a fluid exit feature extending between said internal lumen and said outer surface, wherein said fluid exit feature is arranged along a longitudinally-extending exit feature centerline, wherein said exit feature is adapted to be placed against tissue, and wherein said internal lumen is adapted to deliver conductive fluid to said fluid exit feature;

an active internal electrode mounted within said internal lumen of said catheter body and adapted to contact said conductive fluid, wherein said active internal electrode is configured to be electrically connected to a source of ablative energy and is adapted to impart said ablative energy to the tissue via said conductive fluid; and

at least one passive external electrode mounted on said outer surface of said catheter body adjacent to said fluid exit feature, wherein said at least one passive external electrode is configured to be electrically connected to said source of ablative energy to return at least a portion of said ablative energy to said source of ablative energy, whereby, upon activation of said source of ablative energy, an electric field is created between said active internal electrode and said at least one passive external electrode, and in the tissue adjacent to said fluid exit feature;

wherein said at least one passive external electrode further comprises;

a first surface electrode mounted on said outer surface of said catheter body adjacent to a first side of said longitudinally-extending exit feature centerline; and

a second surface electrode mounted on said outer surface of said catheter body adjacent to a second side of said longitudinally-extending exit feature centerline.

38. A multipolar, virtual-electrode catheter for performing radiofrequency ablation of cardiac tissue, the catheter comprising:

a catheter body defining an outer surface and an internal lumen, wherein said internal lumen is adapted to carry conductive fluid;

at least two metal electrodes positioned on said outer surface of said catheter body, wherein said at least two metal electrodes are adapted for placement against the cardiac tissue, wherein at least one of said at least two metal electrodes is configured to be connected to a return end of an RF source;

a metal conductor positioned within said internal lumen and adapted to impart radiofrequency energy to the conductive fluid, wherein said internal flexible conductor is configured to be connected to the RF source to supply the radiofrequency energy;

at least one opening on said outer surface of said catheter, said at least one opening adapted to create a flow path for the conductive fluid in said internal lumen to flow out of the catheter and impinge upon the cardiac tissue as a virtual-electrode, wherein said at least one opening is arranged along a longitudinally-extending opening centerline, and wherein said at least two metal electrodes further comprise;

a first surface electrode mounted on said outer surface of said catheter body adjacent to a first side of said longitudinally-extending opening centerline; and

a second surface electrode mounted on said outer surface of said catheter body adjacent to a second side of said longitudinally-extending opening centerline; and

at least one temperature sensor on said outer surface of said catheter body in close juxtaposition to said at least two metal electrodes, wherein the internal flexible conductor operates as an active electrode when connected to the RF source, wherein at least one of the at least two metal electrodes operates as an inactive return electrode to capture and return at least a portion of the RF energy to the RF source when the at least one of the at least two metal electrodes is connected to the return end of the RF source, thereby creating an electric field between the metal conductor and at least one of the first surface electrode and the second surface electrode.

39. The multipolar, virtual-electrode catheter of claim 38, further comprising a shaping wire provided separate from the metal conductor.