Methods and compositions for tissue regeneration
First Claim
Patent Images
1. A composition comprising:
- (a) cells comprising keratinocytes or fibroblasts, or mixtures thereof, that secrete one or more biologically active molecules selected from the group consisting of GM-CSF, VEGF, KGF, bFGF, TGFβ
, angiopoietin, EGF, IL-Iβ
, IL-6, IL-8, TGFα
, and TNFα
;
(b) an extracellular matrix comprising alginate;
(c) a buffered solution; and
(d) human serum albumin or a cryoprotectant,wherein the cells are allogeneic and mitotically inactive.
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Abstract
Disclosed is a composition comprising cells comprising keratinocytes or fibroblasts, or mixtures thereof, that secrete one or more biologically active molecules selected from the group consisting of GM-CSF, VEGF, KGF, bFGF, TGFβ, angiopoietin, EGF, IL-ID, IL-6, IL-8, TGFα, and TNFα and an extracellular matrix comprising alginate, wherein the cells are allogeneic and mitotically inactive.
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Citations
12 Claims
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1. A composition comprising:
-
(a) cells comprising keratinocytes or fibroblasts, or mixtures thereof, that secrete one or more biologically active molecules selected from the group consisting of GM-CSF, VEGF, KGF, bFGF, TGFβ
, angiopoietin, EGF, IL-Iβ
, IL-6, IL-8, TGFα
, and TNFα
;(b) an extracellular matrix comprising alginate; (c) a buffered solution; and (d) human serum albumin or a cryoprotectant, wherein the cells are allogeneic and mitotically inactive. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification