X-ray mammography/tomosynthesis of patient's breast

• US 7,881,428 B2
• Filed: 08/14/2009
• Issued: 02/01/2011
• Est. Priority Date: 08/15/2005
• Status: Active Grant

• Current Assignee: Hologic Incorporated
• Original Assignee: Hologic Incorporated
• Inventors: Smith, Andrew P, Shaw, Ian, Stein, Jay, Defreitas, Ken, Jing, Zhenxue, Farbizio, Tom, Ruth, Christopher, Ren, Baorui, Niklason, Loren
• Primary Examiner(s): THOMAS, COURTNEY D
• Application Number:
  US12/541,715
• Publication Number:
  US 20090304147A1
• Time in Patent Office: 536 Days
• Field of Search: 378/37, 378/62, 378/96, 378/97, 378/108, 378/901, 382/131, 382/132
• US Class Current: 378/37
• CPC Class Codes: A61B 6/025 Tomosynthesis
• CPC Class Codes: A61B 6/102 Protection against mechanical damage, e.g. anti-collision devices
• CPC Class Codes: A61B 6/4028 resulting in acquisition of views from substantially different positions, e.g. EBCT
• CPC Class Codes: A61B 6/4417 related to combined acquisition of different diagnostic modalities
• CPC Class Codes: A61B 6/4429 related to the mounting of source units and detector units
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography
• CPC Class Codes: A61B 6/583 using calibration phantoms

Abstract

A breast x-ray system and method using tomosynthesis imaging in which the x-ray source generally moves away from the patient'"'"'s head. The system may include an operation mode in which it additionally takes mammogram image data.

Claims

1. A method of imaging a patient'"'"'s breast with x-rays using a combined mammography and tomosynthesis x-ray system, said method comprising:

acquiring (i) an x-ray mammogram image Mp and (ii) several projection tomosynthesis images Tp of a patient'"'"'s breast in a selected time sequence;

wherein the projection images Tp are acquired using an imaging x-ray beam directed at the patient'"'"'s breast at respective different angles;

generating auto exposure control (AEC) information by computer-processing x-ray data obtained in connection with at least one of said (i) mammogram image Mp and (ii) one or more of said projection images Tp, before acquiring the other of said (i) mammogram image Mp and (ii) one or more projection images Tp; and

using the generated AEC information to control x-ray exposure in acquiring the other of said (i) mammogram image Mp and (ii) one or more projection images Tp.

2. A method as in claim 1 in which said acquiring comprises acquiring the mammogram image Mp at x-ray energies different from those used in acquiring the projection images Tp and the using step comprises using a computer-implemented look-up table relating x-ray exposure information for acquiring said mammogram image Mp with x-ray exposure information for acquiring said projection images Tp, taking into account said different x-ray energies.

3. A method as in claim 1 in said generating and using comprise generating AEC information obtained in connection with said Mp image and using the generated information in acquiring said Tp images.

4. A method as in claim 1 in which the AEC information is obtained in a pre-pulse, low-dose x-ray exposure of the breast taken before and in connection with taking said Mp image.

5. A method as in claim 1 in said generating and using comprise generating AEC information from one or more of said projection images Tp and using the generated information in acquiring said Mp image.

6. A method as in claim 1 in which said generating and using comprise generating AEC information from one or more but less than all of said projection images Tp and using the generated information in acquiring others of said Tp images.

7. A method as in claim 6 in which the AEC information generated from the one or more of the projection images Tp is generated using an x-ray exposure of the breast at a dose different from that for the other Tp images.

8. A method of imaging a patient'"'"'s breast with x-rays using a tomosynthesis x-ray system, said method comprising:

acquiring several projection tomosynthesis images Tp of a patient'"'"'s breast in a selected time sequence;

wherein the projection images Tp are acquired using an imaging x-ray beam directed at the patient'"'"'s breast at respective different angles;

reconstructing said projection images Tp by computer processing into quality assurance reconstructed preview slice images Trq each representing a respective three-dimensional slice of the patient'"'"'s breast that has a selected thickness and orientation relative to the breast;

displaying said preview slice images Trq; and

selectively reconstructing said projection images Tp into reconstructed slice images Tr through more extensive computer processing than for said preview slice image Trq.

9. A method as in claim 8 in which said preview slice images Trq are characterized by one or more of coarser resolution, greater separation between the slices they represent, greater thickness of the slices they represent, and fewer images compared with said slice images Tr.

10. A method as in claim 8 further including:

reconstructing one or more of said projection images Tp by computer processing into one or more respective quality assurance preview projection images Tpq characterized by coarser resolution than the respective projection images Tp;

displaying the preview projection images Tpq.

11. A method as in claim 8 including selectively reconstructing one or more of said projection images Tp by computer processing into one or more respective quality assurance preview projection images Tpq characterized by coarser resolution than the respective projection images Tp, in which said displaying comprises displaying at least some of the quality assurance images Tpq and Trq by scrolling therethrough on a display.

12. A method as in claim 8 including selectively reconstructing one or more of said projection images Tp by computer processing into one or more respective quality assurance preview projection images Tpq characterized by coarser resolution than the respective projection images Tp, in which said displaying comprises displaying at least some of the quality assurance images Tpq and Trq dynamically in a ciné

loop.

13. A method as in claim 8 including selectively reconstructing one or more of said projection images Tp by computer processing into one or more respective quality assurance preview projection images Tpq characterized by coarser resolution than the respective projection images Tp, in which said displaying comprises displaying at least some of the quality assurance images Tpq and Trq concurrently.

14. A method of imaging a patient'"'"'s breast with x-rays using a tomosynthesis x-ray system, said method comprising:

acquiring several projection tomosynthesis images Tp of a patient'"'"'s breast;

wherein the projection images Tp are acquired using an imaging x-ray beam directed at the patient'"'"'s breast at respective different angles;

computer-processing said projection images Tp to generate one or more respective quality assurance preview projection images Tpq;

wherein each of said quality assurance preview projection images Tpq is characterized by coarser resolution than a respective one of said projection images Tp; and

displaying said one or more quality assurance preview projection images Tpq.

15. A method of imaging a patient'"'"'s breast with x-rays using a tomosynthesis x-ray system, said method comprising:

acquiring several projection tomosynthesis images Tp of a patient'"'"'s breast in a selected time sequence;

wherein the projection images Tp are acquired using an imaging x-ray beam directed at the patient'"'"'s breast at respective different angles;

computer-processing at least some of the projection images Tp into reconstructed slice images Tr each representing a three-dimensional slice of the breast having a selected thickness and a selected orientation relative to the breast;

displaying both said projection images Tp and said slice images Tr.

16. A method as in claim 15 in which said displaying comprises concurrently displaying at least some of said projection images Tp and at least some of said slice images Tr.

17. A method as in claim 15 in which said displaying comprises sequentially displaying at least some of said projection images Tp and at least some of said slice images Tr.

18. A method of imaging a patient'"'"'s breast with x-rays using a combined mammography and tomosynthesis x-ray system, said method comprising:

acquiring an x-ray mammogram image Mp and several projection tomosynthesis images Tp of a patient'"'"'s breast;

wherein the projection images Tp are acquired using an imaging x-ray beam directed at the patient'"'"'s breast at respective different angles;

wherein the mammogram image is acquired at a fine spatial resolution compared with the projection images Tp and said projection images are acquired at a coarse spatial resolution compared with the mammogram image Mp;

reconstructing said coarse resolution projection images Tp by computer processing into reconstructed slice images Tr each representing a respective three-dimensional slice of the patient'"'"'s breast that has a selected thickness and orientation relative to the breast;

displaying said mammogram image Mp and at least one or more of said slice images Tr.

19. A method as in claim 18 in which the step of acquiring said projection images Tp at a coarse spatial resolution comprises acquiring projection images at said respective angles using an array of image pixels as for acquiring said mammogram image Mp but binning pixel values output by said image pixels into a lesser number of pixel values for computer processing into said slice images Tr.

20. A method as in claim 19 in which said binning is asymmetrical so that the spatial resolution of said projection images Tp after binning is coarser in a direction corresponding to a direction of motion of said imaging x-ray beam relative to the breast.

21. A combined mammography and tomosynthesis system imaging a patient'"'"'s breast with x-rays comprising:

an x-ray image acquisition unit comprising a breast immobilizer, an x-ray source at one side of the immobilizer selectively directing an imaging x-ray beam at a patient'"'"'s breast in said immobilizer, and an x-ray imager at an opposite side of the immobilizer receiving the imaging beam;

a control selectively causing the image acquisition unit to acquire x-ray data related to a mammogram image Mp and to several projection tomosynthesis images Tp of a patient'"'"'s breast in the immobilizer;

wherein the x-ray data related to the projection images Tp are acquired with the imaging x-ray beam directed at the patient'"'"'s breast at respective different angles;

said control including a processor generating auto exposure control (AEC) information by computer-processing said x-ray data related to at least one of said (i) mammogram image Mp and (ii) one or more of said projection images Tp, before causing the image acquisition unit to acquire the x-ray data related to the other of said (i) mammogram image Mp and said (ii) one or more projection images Tp; and

said control using the generated AEC information to control x-ray exposure by said imaging x-ray beam in causing the acquisition of x-ray data related to the other of said (i) mammogram image Mp and (ii) one or more projection images Tp.

22. A breast tomosynthesis system imaging a patient'"'"'s breast with x-rays comprising:

an x-ray image acquisition unit comprising a breast immobilizer, an x-ray source at one side of the immobilizer selectively directing an imaging x-ray beam at a patient'"'"'s breast in said immobilizer, and an x-ray imager at an opposite side of the immobilizer receiving the imaging beam;

a control selectively causing the image acquisition unit to acquire x-ray data related to several projection tomosynthesis images Tp of a patient'"'"'s breast in the immobilizer;

wherein the x-ray data related to the projection images Tp are acquired with the imaging x-ray beam directed at the patient'"'"'s breast at respective different angles;

an imager receiving said x-ray data related to said projection images Tp and computer-processing the x-ray data into quality assurance preview images that are at lower spatial resolution than said projection images Tp; and

a display unit displaying said preview images.

23. A system as in claim 22 in which said imager processes the x-ray data related to said projection images Tp into x-ray data describing reconstructed slice images Tr each representing a respective three-dimensional slice of the patient'"'"'s breast having a respective thickness and a respective orientation relative to the breast, wherein said preview images have lower resolution than said slice images, and in which said display unit displays at least some of the slice images Tr.

24. A breast tomosynthesis system imaging a patient'"'"'s breast with x-rays comprising:

an x-ray image acquisition unit comprising a breast immobilizer, an x-ray source at one side of the immobilizer selectively directing an imaging x-ray beam at a patient'"'"'s breast in said immobilizer, and an x-ray imager at an opposite side of the immobilizer receiving the imaging beam;

a control selectively causing the image acquisition unit to acquire x-ray data related to several projection tomosynthesis images Tp of a patient'"'"'s breast in the immobilizer;

wherein the x-ray data related to the projection images Tp are acquired with the imaging x-ray beam directed at the patient'"'"'s breast at respective different angles;

a processor receiving the x-ray data related to the projection images Tp and binning the received data into x-ray data representing coarser projection images Tpc having coarser resolution that said projection images Tp;

an imager receiving the x-ray data representing the coarser resolution images Tpc and processing the received data into x-ray data describing reconstructed slice images Tr each representing a respective three-dimensional slice of the patient'"'"'s breast having a respective thickness and a respective orientation relative to the breast; and

a display displaying at least some of the reconstructed slice images Tr.

25. A combined mammography and tomosynthesis system imaging a patient'"'"'s breast with x-rays comprising:

an x-ray image acquisition unit comprising a breast immobilizer, an x-ray source at one side of the immobilizer selectively directing an imaging x-ray beam at a patient'"'"'s breast in said immobilizer, and an x-ray imager at an opposite side of the immobilizer receiving the imaging beam;

a control selectively causing the image acquisition unit to acquire x-ray data related to a mammogram and to several projection tomosynthesis images Tp of a patient'"'"'s breast in the immobilizer;

wherein the projection images Tp are acquired with the imaging x-ray beam directed at the patient'"'"'s breast at respective different angles;

an imager receiving said x-ray data related to said projection images Tp and computer-processing the x-ray data into x-ray data describing reconstructed slice images Tr each representing a respective three-dimensional slice of the patient'"'"'s breast having a respective thickness and a respective orientation relative to the breast; and

a display displaying both said projection images Tr and said reconstructed slice images Tr.