Mixing and delivery of therapeutic compositions

• US 7,883,490 B2
• Filed: 10/23/2002
• Issued: 02/08/2011
• Est. Priority Date: 10/23/2002
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Damiano, Bud, Casey, Thomas V. II
• Primary Examiner(s): Sirmons; Kevin C
• Assistant Examiner(s): WITCZAK, CATHERINE
• Application Number:
  US10/278,248
• Publication Number:
  US 20040092883A1
• Time in Patent Office: 3,030 Days
• Field of Search: 604/82, 604/83, 604/87, 604/88, 604/89, 604/90, 604/91, 604/92, 604/181, 604/187, 604/232, 604/416
• US Class Current: 604/82
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/284 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/286 upon internal pressure increase, e.g. pierced or burst A61M5/283 takes precedence

Abstract

Syringe systems for mixing and delivery of particles into the body are disclosed. In some embodiments, a mixing and delivery medical syringe system can include a barrel including first and second detachable sections, and first and second compartments communicable through a conduit.

Claims

1. A mixing and delivery medical syringe system, comprising:

a syringe barrel including an upper compartment and a lower compartment;

wherein the upper compartment and the lower compartment are detachably connectable to each other;

a failure membrane disposed in the upper compartment;

wherein the failure membrane is planar and includes;

a first peripheral region having a first thickness,

a second region connected to the first peripheral region, the second region having a second thickness less than the first thickness,

a third region connected to the second region, the third region having a third thickness that is equal to the first thickness,

a fourth region connected to the third region, the fourth region having a fourth thickness that is less than the first thickness and that is greater than the second thickness, and

a fifth peripheral region connected to the fourth region, the fifth peripheral region having a fifth thickness that is equal to the first thickness;

a vial of embolic material disposed in the upper compartment;

a vial of contrast agent disposed in the lower compartment; and

a plunger having a base.

2. The system of claim 1, wherein the upper compartment has a female connector on a bottom end thereof.

3. The system of claim 2, wherein the lower compartment has a male connector on a top end thereof, the male connector being configured to connect with the female connector.

4. The system of claim 1, wherein the second region of the failure membrane is a failure region.

5. The system of claim 1, wherein the fourth region of the failure membrane is a hinge region.

6. The system of claim 5, wherein the failure membrane is circular and has a circumference, and wherein the hinge region extends along a short segment of the circumference of the failure membrane.

7. The system of claim 1, wherein the failure membrane includes cellulose acetate.

8. The system of claim 1, wherein the vial of embolic material includes saline.

9. The system of claim 1, further comprising a stopcock attached to the lower compartment.