Hybrid optical-electrical probes

• US 7,883,536 B1
• Filed: 01/22/2008
• Issued: 02/08/2011
• Est. Priority Date: 01/19/2007
• Status: Active Grant

• Current Assignee: Nervesense Ltd
• Original Assignee: Lockheed Martin Corporation (Martin Marietta Corporation)
• Inventors: Bendett, Mark P., Webb, James S.
• Primary Examiner(s): Johnson, III; Henry M
• Assistant Examiner(s): LIPITZ, JEFFREY BRIAN
• Application Number:
  US12/018,185
• Time in Patent Office: 1,113 Days
• Field of Search: 607/88, 607/89
• US Class Current: 607/89
• CPC Class Codes: A61N 2005/0605 Ear
• CPC Class Codes: A61N 2005/063 comprising light transmitting means, e.g. optical fibres
• CPC Class Codes: A61N 2005/0647 the applicator adapted to be worn on the head
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 5/0603 for treatment of body cavities
• CPC Class Codes: A61N 5/0622 Optical stimulation for exciting neural tissue

Abstract

An optical-signal vestibular-nerve stimulation device and method that provides different nerve stimulation signals to a plurality of different vestibular nerves, including at least some of the three semicircular canal nerves and the two otolith organ nerves. In some embodiments, balance conditions of the person are sensed by the implanted device, and based on the sensed balance conditions, varying infrared (IR) nerve-stimulation signals are sent to a plurality of the different vestibular nerves.

Claims

1. A method for optically stimulating a tissue of an animal and transmitting an elicited electrical response caused by the stimulating, the method comprising:

obtaining light from an optical source, wherein the light is suitable to optically stimulate the tissue of the animal to elicit the electrical response;

providing an optical fiber having a longitudinal axis and operatively coupled to the optical source and configured to transmit the light obtained from the optical source, wherein a plurality of electrical conductors including a first electrical conductor having an insulation-covered portion and an exposed conductor electrode portion and a second electrical conductor having an insulation-covered portion and an exposed conductor electrode portion has been deposited on the optical fiber, wherein the exposed conductor electrode of the first electrical conductor is longitudinally offset along the optical fiber from the exposed conductor electrode of the second electrical conductor relative to the longitudinal axis of the optical fiber;

electromagnetically shielding the first electrical conductor using the second electrical conductor;

aligning the optical fiber such that the obtained light is directed toward the tissue of the animal;

transmitting the light through the optical fiber between the optical source and the tissue of the animal and optically stimulating a nerve action potential in the tissue of the animal using the transmitted light;

detecting an electric field, elicited by the optical stimulation of the tissue of the animal, using the plurality of electrical conductors; and

transmitting electrical signals corresponding to the detected electric field using the plurality of electrical conductors deposited on the optical fiber.

2. The method of claim 1, wherein the transmitting includes transmitting different amounts of the light through a plurality of waveguides, at least one of which is in the optical fiber, to stimulate respective nerves of each of a plurality of inner-ear balance organs.

3. The method of claim 1, wherein the transmitting includes transmitting different wavelengths of the light to stimulate respective nerves of each of a plurality of inner-ear balance organs.

4. The method of claim 1, wherein the obtaining light includes implanting a self-contained IR laser device.

5. The method of claim 1, wherein the obtaining light includes implanting a self-contained battery-powered device.

6. The method of claim 1, wherein the animal is a human person.

7. The method of claim 6, further comprising sensing a condition that affects balance using the conductors deposited on the optical fiber, and wherein the transmitting includes transmitting different light signals to each of a plurality of different balance-sense organs to provide the person sense-of-balance nerve stimulation.

8. The method of claim 1, wherein the providing of the optical fiber includes depositing the at least one electrical conductor as a metalized coating on the optical fiber.

9. The method of claim 1, wherein the providing of the optical fiber includes depositing the at least one electrical conductor as a metal film on the optical fiber.

10. The method of claim 1, wherein the providing of the optical fiber includes forming a plurality of electrical conductors on the optical fiber such that the plurality of electrical conductors includes the first electrical conductor and a second electrical conductor, and such that the first electrical conductor is electrically isolated from the second electrical conductor.

11. An apparatus for optical stimulation of a nerve of an animal to cause a nerve action potential in the nerve of the animal and for transmission of an elicited electrical response caused by the stimulation, the apparatus comprising:

an optical source;

an optical transmission medium having a longitudinal axis and operatively coupled to the optical source and configured to transmit light from the optical source to respective nerves of each of one or more organs of the animal in order to stimulate the respective nerves such that the transmitted light causes the nerve action potential in the respective nerves;

an electrical amplifier; and

a plurality of electrical transmission media including a first electrical transmission medium having an insulation-covered portion and an exposed conductor electrode and a second electrical transmission medium having an insulation-covered portion and an exposed conductor electrode, wherein the plurality of electrical transmission media is deposited on and integral with the optical transmission medium and operatively coupled to the electrical amplifier, wherein the plurality of electrical transmission media is configured to transmit an electrical signal from the respective nerves to the electrical amplifier, wherein the electrical signal is based on the nerve action potential caused by the optical stimulation of the respective nerves, wherein the exposed conductor electrode of the first electrical transmission medium is longitudinally offset along the optical transmission medium from the exposed conductor electrode of the second electrical transmission medium relative to the longitudinal axis of the optical transmission medium such that the plurality of electrical transmission media are configured to detect an electric field, and wherein the second electrical transmission medium electromagnetically shields the first electrical transmission medium.

12. The apparatus of claim 11, wherein the optical transmission medium includes a plurality of optical waveguides and the optical source couples different amounts of the light through the plurality of optical waveguides to stimulate different respective nerves of each of the plurality of inner-ear balance organs.

13. The apparatus of claim 11, wherein the optical source couples different wavelengths of the light to stimulate different respective nerves of each of the plurality of inner-ear balance organs.

14. The apparatus of claim 11, wherein the optical source includes a self-contained implantable IR laser device.

15. The apparatus of claim 11, wherein the optical source includes a self-contained battery-powered device.

16. The apparatus of claim 11, wherein the animal is a human person.

17. The apparatus of claim 16, further comprising at least one sensor configured to sense a condition that affects balance, and wherein the optical transmission medium transmits different light signals, based on the sensed condition, to each of a plurality of different balance-sense organs to provide the person sense-of-balance nerve stimulation.

18. The apparatus of claim 11, wherein the at least one electrical transmission medium includes two or more electrical transmission mediums including a first electrical transmission medium and a second electrical transmission medium, and wherein the first electrical transmission medium is electrically isolated from the second electrical transmission medium.

19. The apparatus of claim 11, further comprising:

an insulator layer surrounding the at least one electrical transmission medium; and

a co-axial metal-film shield layer deposited on the insulator layer.

20. An apparatus for optical stimulation of a nerve of an animal and for transmission of an elicited electrical response caused by the optical stimulation, the apparatus comprising:

an optical source operable to emit a light signal that will cause a nerve action potential response in the nerve of the animal;

means for transmitting the light signal to the nerve of the animal in order to cause the nerve action potential response in the nerve of the animal, wherein the means for transmitting the light signal has a longitudinal axis;

means for aligning the optical fiber means to direct the light signal toward the nerve of the animal; and

means for transmitting electrical signals corresponding to the nerve action potential response in the nerve caused by the optical stimulation of the nerve by the light signal, wherein the means for transmitting electrical signals is deposited on the means for transmitting the light signal, wherein the means for transmitting electrical signals is configured to detect an electric field, and wherein the means for transmitting electrical signals includes a first means for transmitting electrical signals having an insulation-covered portion and an exposed electrode means portion and a second means for transmitting electrical signals wherein the second means for transmitting electrical signals includes means for shielding the first means for transmitting electrical signals, wherein the second means for transmitting electrical signals includes an insulation-covered portion and an exposed electrode means portion, and wherein the exposed portion of the first means for transmitting electrical signals is longitudinally offset along the means for transmitting the light signal from the exposed portion of the second means for transmitting electrical signals.

21. The apparatus of claim 20, wherein the optical fiber means for transmitting includes means for transmitting different amounts of the light to stimulate respective nerves of each of the plurality of inner-ear balance organs.

22. The apparatus of claim 20, wherein the optical fiber means for transmitting includes means for transmitting different wavelengths of the light to stimulate respective nerves of each of the plurality of inner-ear balance organs.

23. The apparatus of claim 20, wherein the optical source includes a self-contained IR laser implantable device.

24. The apparatus of claim 20, wherein the optical source includes a self-contained battery-powered implantable device.

25. The apparatus of claim 20, wherein the animal is a human person, and the apparatus further comprises means for sensing a condition that affects balance, and wherein the means for transmitting includes means for transmitting different light signals, based on the sensed condition, to each of a plurality of different balance-sense organs to provide the person sense-of-balance nerve stimulation.

26. The apparatus of claim 20, further comprising means for electromagnetically shielding the means for transmitting electrical signals.

27. An apparatus for optical stimulation of a nerve of an animal to cause a nerve action potential in the nerve of the animal and for transmission of an elicited electrical response caused by the stimulation, the apparatus comprising:

an optical source;

an optical transmission medium having a longitudinal axis and operatively coupled to the optical source and configured to transmit light from the optical source to respective nerves of each of one or more organs of the animal in order to stimulate the respective nerves such that the transmitted light causes the nerve action potential in the respective nerves;

an electrical amplifier; and

a plurality of electrical transmission media including a first electrical transmission medium having an insulation-covered portion and an exposed conductor electrode and a second electrical transmission medium having an insulation-covered portion and an exposed conductor electrode, wherein the plurality of electrical transmission media is deposited on and integral with the optical transmission medium and operatively coupled to the electrical amplifier, wherein the plurality of electrical transmission media is configured to transmit an electrical signal from the respective nerves to the electrical amplifier, wherein the electrical signal is based on the nerve action potential caused by the optical stimulation of the respective nerves, wherein the exposed conductor electrode of the first electrical transmission medium is longitudinally offset along the optical transmission medium from the exposed conductor electrode of the second electrical transmission medium relative to the longitudinal axis of the optical transmission medium such that the plurality of electrical transmission media are configured to detect an electric field, and wherein the first electrical transmission medium and the second electrical transmission medium are deposited on the optical transmission medium in a helical pattern around the optical transmission medium.