Reservoir device for intraocular drug delivery
First Claim
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1. A sustained release delivery device for delivering an agent to the interior of a patient'"'"'s eye, comprising:
- an expandable reservoir having a proximal end and a distal end;
a hollow body at least partially housed within the reservoir, the hollow body having a proximal end and a distal end, wherein at least the proximal end of the hollow body extends out of the proximal end of the reservoir, and wherein the reservoir is fabricated of a pliable or elastomeric material that enables folding, rolling or compression of the reservoir about the hollow body, such that the cross section of the device with the reservoir folded, rolled, or compressed is about 1 mm or less;
an inlet port in the hollow body for injection of an agent into the hollow body;
one or more openings in the hollow body in communication with the reservoir for delivery of an agent from the hollow body to the reservoir; and
a delivery mechanism for delivering the agent from the reservoir to the interior of a patient'"'"'s eye at a desired rate.
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Abstract
A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.
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Citations
40 Claims
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1. A sustained release delivery device for delivering an agent to the interior of a patient'"'"'s eye, comprising:
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an expandable reservoir having a proximal end and a distal end; a hollow body at least partially housed within the reservoir, the hollow body having a proximal end and a distal end, wherein at least the proximal end of the hollow body extends out of the proximal end of the reservoir, and wherein the reservoir is fabricated of a pliable or elastomeric material that enables folding, rolling or compression of the reservoir about the hollow body, such that the cross section of the device with the reservoir folded, rolled, or compressed is about 1 mm or less; an inlet port in the hollow body for injection of an agent into the hollow body; one or more openings in the hollow body in communication with the reservoir for delivery of an agent from the hollow body to the reservoir; and a delivery mechanism for delivering the agent from the reservoir to the interior of a patient'"'"'s eye at a desired rate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 34, 35, 36, 37, 38, 39, 40)
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16. A sustained release delivery device for delivering an agent to a patient, comprising:
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a hollow body having a proximal end and a distal end; an inlet port at the proximal end of the hollow body for injection of the agent; an expandable reservoir covering at least a portion of the hollow body, the reservoir fabricated of an elastomeric material that enables folding, rolling or compression of the reservoir about the hollow body such that the cross section of the device with the reservoir folded, rolled, or compressed is about 1 mm or less; at least one aperture in the hollow body for providing communication between the hollow body and the reservoir; a delivery mechanism for delivering the agent to the patient, the delivery mechanism in communication with the reservoir, whereby therapeutic agent injected through the inlet port travels into the reservoir and flows out of the reservoir through the delivery mechanism at a desired rate, and whereby the device utilizes the elastomeric properties of the reservoir housing the agent to deliver the agent from the reservoir to a treatment site at a desired rate. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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Specification