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Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation

  • US 7,884,053 B2
  • Filed: 12/26/2006
  • Issued: 02/08/2011
  • Est. Priority Date: 03/09/2001
  • Status: Expired due to Fees
First Claim
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1. A compound library comprising at least one set of terminal oligomer blocks and at least two sets of condensing oligomer blocks, wherein:

  • (a) each set of oligomer blocks comprises two or more different oligomers;

    (b) the oligomer blocks of each set are independently either peptide nucleic acid oligomer, PNA chimera or PNA combination oligomer;

    (c) the oligomer blocks are selected to comprise functional moieties that form a linker of at least three atoms in length that covalently links the oligomer blocks when a terminal oligomer block is condensed with a condensation oligomer block;

    (d) the oligomer blocks are not support bound;

    (e) the oligomer blocks do not comprise nucleobase-protecting groups;

    (f) all of the oligomer blocks of a set of condensing oligomer blocks contain the same independently detectable reporter moiety; and

    (g) all of the oligomer blocks of the at least one set of terminal oligomer blocks comprise the same quencher moiety,with the further proviso that the compound library is a bifunctional single set library.

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