Optical chemical detector and method

• US 7,885,490 B2
• Filed: 03/10/2008
• Issued: 02/08/2011
• Est. Priority Date: 03/10/2008
• Status: Active Grant

• Current Assignee: OctroliX B.V.
• Original Assignee: OctroliX B.V.
• Inventors: Heideman, Rene Gerrit, Dekker, Ronald
• Primary Examiner(s): Peace; Rhonda S
• Application Number:
  US12/045,570
• Publication Number:
  US 20090226127A1
• Time in Patent Office: 1,065 Days
• Field of Search: 385/12
• US Class Current: 385/12
• CPC Class Codes: B01L 2200/10 Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
• CPC Class Codes: B01L 2300/0654 Lenses; Optical fibres
• CPC Class Codes: B01L 2300/0867 Multiple inlets and one sample wells, e.g. mixing, dilution
• CPC Class Codes: B01L 2400/0421 electrophoretic flow
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: G01N 21/45 using interferometric methods; using Schlieren methods
• CPC Class Codes: G01N 21/7746 the waveguide coupled to a cavity resonator
• CPC Class Codes: G01N 27/44721 by optical means
• CPC Class Codes: H01S 5/14 External cavity lasers H01S5/18 takes precedence; mode locking H01S5/065

Abstract

An apparatus and method for optically detecting the presence of an analyte in a solution is presented. An embodiment comprises a waveguide resonator that is optically coupled to a fluid in a fluidic conduit so that the resonant wavelength of the waveguide resonator is based on the refractive index of the fluid.

Claims

1. A sensor comprising:

a fluidic conduit for conveying a fluid, wherein the fluidic conduit comprises a first region;

a first waveguide resonator, wherein the first waveguide resonator is optically resonant for a first spectral component when the fluid in the first region has a first refractive index, and wherein the first waveguide resonator is optically resonant for a second spectral component when the fluid in the first region has a second refractive index;

a first bus waveguide and a second bus waveguide, wherein the first waveguide resonator comprises the first bus waveguide and the second bus waveguide; and

an input port, wherein the input port, first bus waveguide and second bus waveguide are optically coupled;

wherein the first waveguide resonator is dimensioned and arranged to return the first spectral component to the input port when the fluid in the first region has the first index of refraction.

2. The sensor of claim 1 wherein the first waveguide resonator comprises a disc resonator.

3. The sensor of claim 1 wherein the first waveguide resonator comprises a ring resonator.

4. The sensor of claim 1 further comprising:

an output port;

wherein the input port distributes the first spectral component into a first light signal in the first bus waveguide and a second light signal in the second bus waveguide;

wherein the output port combines the first light signal and the second light signal; and

wherein the first waveguide resonator interposes the input port and the output port.

5. The sensor of claim 1 further comprising a second waveguide resonator, wherein the fluidic conduit comprises a second region and the second waveguide resonator and the fluidic conduit are optically coupled at the second region;

wherein the second waveguide resonator is optically resonant for the first spectral component when the fluid in the second region has the first refractive index, and wherein the second waveguide resonator is optically resonant for the second spectral component when the fluid in the second region has the second refractive index.

6. A sensor for detecting the presence of an analyte in a fluid comprising:

a fluidic conduit for providing the fluid at a first region;

a first waveguide resonator, wherein the first waveguide resonator and the fluid are optically coupled at the first region, and wherein the first waveguide resonator is dimensioned and arranged to receive a first light signal and provide a second light signal that is based on the first light signal, and further wherein the second light signal has a first intensity when the fluid is analyte-free and a second intensity when the fluid comprises the analyte;

a first bus waveguide and a second bus waveguide, wherein the first waveguide resonator comprises the first bus waveguide and the second bus waveguide; and

an input port, wherein the input port, first bus waveguide, and second bus waveguide are optically coupled, and wherein the first waveguide resonator is dimensioned and arranged to reflect a first spectral component to the input port when the fluid in the first region is analyte-free and a second spectral component to the input port when the fluid in the first region comprises the analyte.

7. The sensor of claim 6 wherein the first waveguide resonator comprises a closed-loop waveguide that comprises a waveguide core having an inner core of stoichiometric silicon oxide (SiO₂), an outer core of stoichiometric silicon nitride (Si₃N₄), and a cladding that comprises the fluid in the first region.

8. The sensor of claim 6 further comprising:

a source for providing the first light signal to the first waveguide resonator; and

a photodetector, wherein the photodetector receives the second light signal from the first waveguide resonator, and wherein the photodetector provides a first electrical signal that is based on the second light signal.

9. The sensor of claim 6 further comprising:

a second waveguide resonator, wherein the second waveguide resonator comprises a second bus waveguide;

wherein the fluidic conduit comprises a second region, and wherein the second waveguide resonator and the fluid are optically coupled at the second region, and further wherein the second waveguide resonator is dimensioned and arranged to receive a third light signal and provide a fourth light signal that is based on the third light signal, and further wherein the fourth light signal has a third intensity when the fluid is analyte-free and a fourth intensity when the fluid comprises the analyte.

10. A method for detecting an analyte in a fluid comprising:

receiving a first light signal at a first waveguide resonator, wherein the first waveguide resonator and the fluid are optically coupled at a first region of a fluidic conduit;

receiving a second light signal from the first waveguide resonator, wherein the second light signal has a first intensity when the fluid in the first region is analyte-free and a second intensity when the fluid in the first region comprises an analyte;

adding a sample to the fluid at a first time, wherein the sample is added at a second region of the fluidic conduit, and wherein the sample comprises the analyte;

inducing a flow of the fluid from the second region to the first region; and

computing a first time differential between the first time and a second time, wherein the second time is based on a change in the intensity of the second signal.

11. The method of claim 10 further comprising providing the first waveguide resonator, wherein the first waveguide resonator is dimensioned and arranged to be optically resonant at a first wavelength when the fluid in the first region is analyte-free and optically resonant at a second wavelength when the fluid in the first region comprises an analyte.

12. The method of claim 11 further comprising:

computing a difference between the first wavelength and the second wavelength; and

computing a concentration of analyte in the fluid at the first region based on the difference between the first wavelength and the second wavelength.

13. The method of claim 10 further comprising determining a property of the analyte based on (1) the time differential and (2) the separation between the second region and the first region.

14. The method of claim 10 further comprising:

transmitting a third light signal to a second waveguide resonator, wherein the second waveguide resonator and the fluid are optically coupled at a third region of the fluidic conduit;

receiving a fourth light signal from the second waveguide resonator, wherein the fourth light signal has a third intensity when the fluid in the third region is analyte-free and a fourth intensity when the fluid in the third region comprises an analyte.

15. The method of claim 14 further comprising:

inducing a flow of the sample from the first region to the third region;

computing a second time differential between the second time and a third time, and wherein the third time is based on a change of the intensity of the fourth signal; and

determining a property of the analyte based on (1) the second time differential and (2) a separation between the first region and the third region.