Method for using photoplethysmography to optimize fluid removal during renal replacement therapy by hemodialysis or hemofiltration
First Claim
1. A method of optimizing fluid removal during renal replacement therapy, said method comprising the steps of:
- securing a first oximetry/photoplethysmography sensor to a central source site of a patient wherein said first sensor is configured to generate a photoplethysmography signal stream from said central source site;
processing said photoplethysmography signal stream to determine blood flow and/or volume status, wherein said processing comprises separating said photoplethysmography signal stream into a pulsatile cardiac component and a venous capacitance component;
monitoring said blood flow and/or volume status; and
adjusting the ultrafiltration rate of said renal replacement therapy responsive to a change in said blood flow and/or volume status indicated at said central source site.
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Accused Products
Abstract
Disclosed herein are methods, systems and devices to monitor vascular volume status during renal replacement therapy utilizing at least one oximetry/photoplethysmography sensor. The methods, systems and devices provide an alternative to conventional vascular volume monitoring methods during renal replacement therapy while enabling reliable, non-invasive, and automatic monitoring of vascular volume to avert patient hypotension. The methods, systems and devices may be employed in the context of both inpatient and outpatient dialysis facilities and may also be incorporated into conventional hemodialysis and hemofiltration techniques and equipment.
46 Citations
19 Claims
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1. A method of optimizing fluid removal during renal replacement therapy, said method comprising the steps of:
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securing a first oximetry/photoplethysmography sensor to a central source site of a patient wherein said first sensor is configured to generate a photoplethysmography signal stream from said central source site; processing said photoplethysmography signal stream to determine blood flow and/or volume status, wherein said processing comprises separating said photoplethysmography signal stream into a pulsatile cardiac component and a venous capacitance component; monitoring said blood flow and/or volume status; and adjusting the ultrafiltration rate of said renal replacement therapy responsive to a change in said blood flow and/or volume status indicated at said central source site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of optimizing fluid removal for a patient undergoing renal replacement therapy comprising:
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securing a first photoplethysmography sensor a central source site of a patient wherein said sensor is configured to generate a photoplethysmography signal stream from said central source site; processing said signal streams received from said first sensor to obtain a separate pulsatile cardiac component signal and a separate venous capacitance component signal; and
;adjusting the ultrafiltration rate so as to modulate said separate pulsatile cardiac component signal or said separate venous capacitance component signal, or both said separate pulsatile cardiac component signal and said separate venouse capacitance component signal to a target level. - View Dependent Claims (10)
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11. A method of optimizing fluid removal during renal replacement therapy, said method comprising the steps of:
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securing a first photoplethysmography sensor to a central source site of a patient wherein said sensor is configured to generate a photoplethysmography signal stream from said central source site; processing said signal streams received from said first sensor to obtain a separate pulsatile cardiac component signal and a separate venous capacitance component signal; evaluating said pulsatile cardiac component signal, or said venous capacitance component signal, or both, to determine when the blood flow and/or volume status changes; and adjusting the ultrafiltration rate of said renal replacement therapy responsive to said blood flow and/or volume status change indicated at said central source site. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
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Specification