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Antisense composition and method for treating muscle atrophy

  • US 7,888,012 B2
  • Filed: 05/11/2006
  • Issued: 02/15/2011
  • Est. Priority Date: 02/09/2005
  • Status: Active Grant
First Claim
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1. An antisense composition, comprising a substantially uncharged antisense compound(i) composed of morpholino subunits and phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′

  • exocyclic carbon of an adjacent subunit,(ii) capable of uptake by target muscle cells in the subject,(iii) containing between 10-40 nucleotide bases, and(iv) having a base sequence that is complementary to at least 12 contiguous bases in a target region of processed human myostatin transcript identified by SEQ ID NO;

    10, where hybridizing of the compound to the target region is effective to block translation of processed human myostatin RNA transcript, andconjugated to the antisense compound, an arginine-rich peptide has the sequence identified by SEQ ID NO;

    9.

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