Test cassette for fluid analyses

• US 7,888,130 B2
• Filed: 11/15/2006
• Issued: 02/15/2011
• Est. Priority Date: 01/03/2006
• Status: Active Grant

• Current Assignee: Draeger Safety Incorporated (FPS Vermögensverwaltung GmbH)
• Original Assignee: Draeger Safety Incorporated (FPS Vermögensverwaltung GmbH)
• Inventors: Wuske, Thomas, Mahn, Jessika, Polzius, Rainer
• Primary Examiner(s): Alexander; Lyle A
• Assistant Examiner(s): WHITE, DENNIS MICHAEL
• Application Number:
  US11/560,140
• Publication Number:
  US 20070154350A1
• Time in Patent Office: 1,553 Days
• Field of Search: 422/55, 422/56, 422/57, 422/58, 422/59, 422/60, 422/61, 422/62, 422/65, 436/169
• US Class Current: 436/169
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2300/1805 Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
• CPC Class Codes: B01L 3/5023 with a sample being transported to, and subsequently stored in an absorbent for analysis

Abstract

A test cassette for the detection of analytes from fluid samples is provided which has a housing (1, 2) with an inlet opening and with a reservoir for receiving a fluid sample containing the analyte. A separate carrier platform (3) can be horizontally displaced in the housing (1, 2), for fixing one or more flexible, strip-like, capillary-active detection elements. The carrier platform (3) in the housing (1, 2) is designed such that the capillary-active detection elements are deflected from the longitudinal direction of the strips and dip into the fluid sample in the reservoir during a lateral motion of the carrier platform (3).

Claims

1. A process for detecting analytes from fluid samples by means of a test cassette, the process comprising:

providing a housing with an inlet opening and with a reservoir for receiving a fluid sample with the analyte;

providing a separate carrier platform, which can be displaced horizontally in said housing selectively toward, and selectively away from, said reservoir;

providing a plurality of flexible, strip-like capillary-active detection elements, for analytes, on the carrier platform in the housing;

inserting a fluid sample into the reservoir in the housing of the test cassette;

providing a reading/evaluating device;

placing said housing with said carrier platform in a reading/evaluating device;

said reading/evaluating device selectively moving said carrier platform inside said housing from an inoperative position toward said reservoir to deflect the detection elements such that the detection elements dip into the reservoir for receiving the fluid sample;

said reading/evaluating device selectively moving said carrier platform away from said reservoir to remove the detection elements from the reservoir and arrange said carrier platform in a reading/evaluating position; and

measuring a biochemical detection reaction by means of said reading/evaluating device on the capillary-active detection elements in said reading/evaluating position to determine the concentration of the analytes.

2. A test cassette system for the detection of analytes from fluid samples, the system comprising:

a housing with an inlet opening and with a reservoir for receiving a fluid sample with the analyte;

a separate carrier platform selectively movably arranged in said housing in a direction selectively toward said reservoir, and selectively away from said reservoir;

a carrier platform strip mount for supporting one or more flexible, strip-like capillary-active detection elements; and

deflection means for deflecting the capillary-active detection elements into said reservoir;

a reading/evaluating device for reading/evaluating the detection elements in a reading/evaluating position, said reading/evaluating device receiving said housing and said carrier platform, said reading/evaluating device including an actuator selectively moving said carrier platform relative to said housing in a direction selectively toward said reservoir, and selectively away from said reservoir.

3. A system in accordance with claim 2, wherein said deflection means comprises defecting elements connected to said housing and a positioning of said carrier platform in said housing allowing movement of said carrier platform relative to said housing whereby motion of said carrier platform brings about a vertical deflection of the flexible and capillary-active detection elements into said reservoir.

4. A system in accordance with claim 2, wherein:

said actuator and said deflecting means cooperate to have movement of said carrier platform deflect the capillary-active detection elements into, and out of, said reservoir while said carrier platform is inside said housing.

5. A system in accordance with claim 4, wherein:

said actuator selectively moves said carrier platform between a sample position where a set of the capillary-active detection elements are deflected into said reservoir, and said reading position where said reading/evaluating device reads/evaluates the capillary-active detection elements.

6. A system in accordance with claim 5, wherein:

said actuator selectively moves said carrier platform to another sample position, where another set of the capillary-active detection elements are deflected into said reservoir.

7. A system in accordance with claim 2, wherein:

said deflection means selectively moves the detection elements into and out of said reservoir.

8. A system in accordance with claim 6, wherein:

said actuator moves said carrier platform between said sample position, said another sample position, and said reading/evaluating position to have the different sets of detection elements be in said reservoir for different amounts of time.

9. A system in accordance with claim 2, wherein:

said housing and said carrier platform include guide structures for guiding the carrier platform with respect to said housing toward and away from said reservoir to move the detection elements into an out of the reservoir while said carrier is moving inside said housing.

10. A system in accordance with claim 2, further comprising:

a temperature control device arranged adjacent to said reservoir for heating and cooling a temperature of a sample in said reservoir.

11. A system in accordance with claim 2, further comprising:

a locking structure on said housing and said carrier platform for selectively locking said carrier platform in an inoperative position with respect to said housing;

unlocking structure in said reading/evaluating device for selectively unlocking said locking structure when said housing and said carrier platform are connected with said reading/evaluating device.