Cardiac activation sequence monitoring and tracking
First Claim
1. A cardiac method, comprising:
- sensing a plurality of composite cardiac signals over time at a plurality of patient-internal locations;
performing one or more source separations using one or more of the sensed plurality of composite signals;
producing one or more cardiac signal vectors indicative of a cardiac depolarization sequence of an area of the heart based on the one or more source separations;
establishing a baseline of a characteristic of the one or more cardiac signal vectors;
performing at least one subsequent source separation using at least one of the sensed plurality of composite signals;
monitoring the characteristic of the one or more cardiac signal vectors based on the at least one subsequent source separation;
detecting a change in the characteristic of the one or more cardiac signal vectors relative to the baseline of the characteristic of the one or more cardiac signal vectors; and
identifying a cardiac condition based on the detected change, wherein performing the one or more source separations, producing the one or more cardiac signal vectors, establishing the baseline, performing the at least one subsequent source separation, monitoring, detecting, and identifying are performed at least in part by circuitry of a medical system.
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Accused Products
Abstract
Cardiac monitoring and/or stimulation methods and systems provide monitoring, diagnosis, and defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, performs a source separation, and produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation. A method of signal separation involves detecting a change in a characteristic of the cardiac signal vector relative to a baseline. One or more vectors and/or activation sequences may be selected, and information associated with the vectors and/or activation sequences may be stored and tracked.
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Citations
36 Claims
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1. A cardiac method, comprising:
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sensing a plurality of composite cardiac signals over time at a plurality of patient-internal locations; performing one or more source separations using one or more of the sensed plurality of composite signals; producing one or more cardiac signal vectors indicative of a cardiac depolarization sequence of an area of the heart based on the one or more source separations; establishing a baseline of a characteristic of the one or more cardiac signal vectors; performing at least one subsequent source separation using at least one of the sensed plurality of composite signals; monitoring the characteristic of the one or more cardiac signal vectors based on the at least one subsequent source separation; detecting a change in the characteristic of the one or more cardiac signal vectors relative to the baseline of the characteristic of the one or more cardiac signal vectors; and identifying a cardiac condition based on the detected change, wherein performing the one or more source separations, producing the one or more cardiac signal vectors, establishing the baseline, performing the at least one subsequent source separation, monitoring, detecting, and identifying are performed at least in part by circuitry of a medical system. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method, comprising:
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sensing, at least in part implantably, a plurality of composite cardiac signals using a plurality of electrodes; performing an initial source separation using one or more of the detected plurality of composite signals, the initial source separation producing vectors; selecting one or more vectors from the plurality of vectors, the one or more selected vectors representative of depolarization of an area of the heart; sensing additional composite cardiac signals; performing a plurality of subsequent source separations using the additional composite cardiac signals; monitoring for a change in the selected one or more vectors between the initial source separation and the subsequent source separations; and detecting anomalous cardiac activity based on the change in the selected one or more vectors. - View Dependent Claims (23, 24, 25, 26)
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27. A cardiac system, comprising:
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a plurality of implantable electrodes configured for sensing a composite signal, thereby providing a plurality of composite signals; a housing configured for implantation in a patient; a controller provided in the housing; a signal processor; and a memory coupled to the signal processor; wherein the signal processor is configured to perform an initial source separation using one or more of the plurality of composite signals, the source separation producing one or more cardiac signal vectors associated with a cardiac depolarization sequence of an area of a heart, store vector information in the memory based on the initial source separation, perform a plurality of subsequent source separations using at least some of the plurality of composite signals that are sensed subsequent to the sensing of the one or more of the plurality of composite signals, monitor for a change in the one or more vectors between the initial source separation and the subsequent source separations using the stored vector information, and to produce an output based on the change in the one or more vectors. - View Dependent Claims (28, 29, 30, 31, 32)
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33. An implantable cardiac device, comprising:
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means for sensing, at least in-part implantably, a plurality of composite signals over time using a plurality of cardiac electrodes; means for performing at least one initial source separation using one or more of the plurality of composite signals, the source separation producing one or more cardiac signal vectors associated with cardiac depolarization of an area of a heart; means for establishing a vector baseline based on the at least one initial source separation; means for performing at least one subsequent source separation using at least one of the plurality of composite signals; means for monitoring for a change in the one or more cardiac signal vectors relative to the vector baseline based on the at least one subsequent source separation; and means for detecting a cardiac condition based on the change in the one or more cardiac signal vectors. - View Dependent Claims (34)
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35. A cardiac method, comprising:
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sensing a plurality of composite cardiac signals over time at a plurality of patient-internal locations; performing, patient-internally, an initial source separation using one or more of the sensed plurality of composite signals; producing, patient-internally, a cardiac signal vector associated with a cardiac depolarization sequence of an area of the heart based on the initial source separation; performing at least one subsequent source separation using at least one of the sensed plurality of composite signals; and detecting a change in the cardiac signal vector between the initial source separation and the at least one subsequent source separation, wherein sensing, performing the initial source separation, producing, performing the at least one subsequent source separation, and detecting are each performed at least in part by circuitry of a medical system.
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36. A cardiac system, comprising:
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a plurality of implantable electrodes configured for sensing composite signals over time, thereby providing a plurality of composite signals; a housing configured for implantation in a patient; a controller provided in the housing and coupled to the plurality of implantable electrodes; and a memory provided in the housing and coupled to the controller; wherein the controller is configured to perform an initial source separation using one or more of the sensed plurality of composite signals, the source separation producing a cardiac signal vector associated with a cardiac depolarization sequence of an area of the heart, perform one or more subsequent source separations using at least one of the plurality of composite signals, and detect a change in the cardiac signal vector indicative of cardiac arrhythmia between the initial source separation and the at least one subsequent source separation.
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Specification