Sensors having protective eluting coating and method therefor

• US 7,890,171 B2
• Filed: 04/20/2007
• Issued: 02/15/2011
• Est. Priority Date: 09/30/2003
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Heil, Ronald W. Jr., Jain, Mudit, Zhu, Qingsheng
• Primary Examiner(s): Manuel; George
• Assistant Examiner(s): Wieland; Robert N
• Application Number:
  US11/738,251
• Publication Number:
  US 20070191921A1
• Time in Patent Office: 1,397 Days
• Field of Search: 600/333, 600/341, 600/310, 600/325, 607/22, 607/17, 607/36, 607/120, 607/129, 607/60, 607/9, 424/419, 427/2.1, 604/264, 604/890.1, 514/365
• US Class Current: 607/22
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61N 1/0568 with drug delivery

Abstract

An apparatus includes an implantable device, such as a chronically implantable device that has a device body. One or more chemical sensors are coupled with the device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.

Claims

1. An apparatus comprising:

an implantable device including at least one of a lead or a cardiac rhythm management device having a device body;

one or more chemical sensors disposed on the device body; and

a drug eluting coating disposed on the one or more chemical sensors, wherein the drug eluting coating prevents fibrotic growth on the one or more chemical sensors.

2. The apparatus of claim 1, wherein the drug eluting coating includes a drug mixed with one or more polymeric binders.

3. The apparatus of claim 1, wherein the drug eluting coating includes a drug eluting matrix that elutes one or more drugs over time.

4. The apparatus of claim 1, wherein the drug eluting coating includes an esterified drug.

5. The apparatus of claim 1, wherein the drug eluting coating includes a pre-compressed drug substance.

6. The apparatus of claim 1, wherein the one or more chemical sensors are coupled to a distal portion of the device body, the distal portion of the device body configured for insertion into a heart of a subject.

7. The apparatus of claim 1, wherein the drug eluting coating comprises a steroid.

8. The apparatus of claim 1, wherein the drug eluting coating comprises dexamethasone.

9. A method comprising:

coupling a chemical sensor with a device body of a lead or a cardiac rhythm management device; and

disposing a drug eluting coating on or directly adjacent to the chemical sensor, wherein the drug eluting coating prevents fibrotic growth on the chemical sensor.

10. The method of claim 9, wherein disposing the drug eluting coating includes painting a drug on an outer surface of at least one of the device body or the chemical sensor.

11. The method of claim 9, further comprising binding a drug with one or more polymers to form the drug eluting coating.

12. The method of claim 9, further comprising compressing a drug with a starch to form the drug eluting coating.

13. The method of claim 9, further comprising mixing a drug with a silicone liquid to form the drug eluting coating.

14. The method of claim 13, further comprising curing the drug and the silicone liquid.

15. The method of claim 9, further comprising mixing a drug with a hydrogel to form the drug eluting coating.

16. The method of claim 9, further comprising esterifying a drug to form the drug eluting coating prior to disposing the drug eluting coating at least one of on, or directly adjacent the chemical sensor.

17. An apparatus comprising:

an implantable device including at least one of a lead or a cardiac rhythm management device having a device body;

one or more chemical sensors disposed on the device body; and

a drug eluting coating disposed directly adjacent the one or more chemical sensors, wherein the drug eluting coating prevents fibrotic growth on the one or more chemical sensors.

18. The apparatus of claim 17, wherein the drug eluting coating includes a drug mixed with one or more polymeric binders.

19. The apparatus of claim 17, wherein the drug eluting coating includes a drug eluting matrix that elutes one or more drugs over time.

20. The apparatus of claim 17, wherein the drug eluting coating includes an esterified drug.

21. The apparatus of claim 17, wherein the drug eluting coating includes a pre-compressed drug substance.

22. The apparatus of claim 17, wherein the drug eluting coating comprises a steroid.

23. The apparatus of claim 17, wherein the drug eluting coating comprises dexamethasone.

24. The apparatus of claim 17, wherein the drug eluting coating is coated on the device body.

25. The apparatus of claim 17, wherein the one or more chemical sensors are defined in part by a sensor outer perimeter, and the drug eluting coating is disposed around the sensor outer perimeter adjacent to the one or more chemical sensors.