Medical instruments and techniques for treating pulmonary disorders

• US 7,892,229 B2
• Filed: 06/22/2005
• Issued: 02/22/2011
• Est. Priority Date: 01/18/2003
• Status: Active Grant

• Current Assignee: Tsunami MedTech, LLC
• Original Assignee: Tsunami MedTech, LLC
• Inventors: Shadduck, John H., Hoey, Michael
• Primary Examiner(s): Dvorak; Linda C
• Assistant Examiner(s): SCOTT, AMANDA L
• Application Number:
  US11/158,930
• Publication Number:
  US 20080132826A1
• Time in Patent Office: 2,071 Days
• Field of Search: 606/24, 606 27- 32, 606 38- 41, 606 45- 50, 607101-105
• US Class Current: 606/41
• CPC Class Codes: A61B 17/32037 for removing obstructions from inner organs or blood vessels, e.g. for atherectomy
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61B 2017/00809 Lung operations
• CPC Class Codes: A61B 2018/00315 for treatment of particular body parts
• CPC Class Codes: A61B 2018/048 in gaseous form

Abstract

A surgical instrument for delivering energy to lung tissue, for example to cause lung volume reduction. In one embodiment, an elongated catheter has a handle portion that includes an interior chamber that is supplied with a biocompatible liquid media under pressure. An energy source delivers energy to the media to cause a liquid-to-vapor phase change within the interior chamber and ejects a flow of vapor media from the working end of the catheter. The delivery of energy and the flow of vapor are controlled by a computer controller to cause a selected pressure and selected volume of vapor to propagate to the extremities of the airways. Contemporaneously, the vapor undergoes a vapor-to-liquid phase transition which delivers a large amount of energy to airway tissue. The thermal energy delivered is equivalent to the heat of vaporization of the fluid media, which shrinks and collapses the treated airways. The treated tissue is the maintained in a collapsed state by means of aspiration for a short interval to enhance tissue remodeling. Thereafter, the patient'"'"'s wound healing response causes fibrosis and further remodeling to cause permanent lung volume reduction.

Claims

1. A method of treating a disorder of a lung comprising:

generating a flow of vapor;

introducing the flow of vapor into a targeted airway of the lung at a pressure sufficient to extend the flow of vapor to extremities of the targeted airway;

delivering thermal energy to the lung tissue via a vapor-to-liquid phase transition of the vapor; and

modifying the lung tissue to treat the disorder.

2. The method of claim 1 further comprising generating the flow of vapor by at least one of resistive heating means, radiofrequency (Rf) energy means, microwave energy means, photonic energy means, magnetic induction energy means, compression and decompression means, and ultrasonic energy means.

3. The method of claim 1, further comprising controlling at least one of the pressure of the flow of vapor, the volume of the flow of vapor and the duration of the flow of vapor.

4. The method of claim 1, further comprising controlling the temperature of the heat of vaporization of the vapor.

5. The method of claim 1 wherein modifying lung tissue includes at least one of shrinkage, denaturation, damage, ablation, sealing, occlusion, an immune response or remodeling of lung tissue.

6. The method of claim 5 wherein the lung tissue includes at least one of bronchi, bronchioles, alveoli, parenchyma, diseased lung tissue, normal lung tissue, collagenous lung tissue and interalveolar collateral ventilation tissue.

7. The method of claim 1 wherein introducing the flow of vapor includes introducing the flow over a sufficiently short interval to substantially prevent conductive heat transfer to body structure external to a targeted airway.

8. The method of claim 1 including generating the vapor from at least one of water, saline and alcohol.

9. The method of claim 1 wherein introducing the flow of vapor includes introducing at least one substance with the vapor.

10. The method of claim 9 wherein the substance is an imaging enhancing media.

11. The method of claim 1 including introducing at least one pharmacologically active agent with the vapor.

12. The method of claim 11 wherein the pharmacologically active agent is at least on one of an anesthetic, an antibiotic, a toxin and a sclerosing agent.

13. The method of claim 1 further comprising imaging the flow of vapor.

14. The method of claim 1 wherein introducing the flow of vapor is preceded by expanding an expansion structure in a proximal portion of a targeted airway for controlling the direction of the flow of vapor.

15. The method of claim 14 wherein expanding the expansion structure includes evacuating air from the airway distal to the expansion structure.

16. The method of claim 1 further comprising the step of applying negative pressure to the targeted airway after terminating the flow of vapor.

17. The method of claim 16 wherein applying negative pressure is performed for an interval sufficient for at least one of tissue cooling and tissue remodeling.

18. The method of claim 1 wherein the heat of vaporization of the vapor is above about 45′

C.

19. The method of claim 1 further comprising coupling electrical energy to the flow of vapor.

20. The method of claim 1 wherein the disorder of the lung comprises emphysema.

21. The method of claim 1 further comprising expanding an occlusion balloon in a proximal portion of the targeted airway to direct the flow of vapor toward the extremities of the targeted airway.

22. A method of treating a disorder of a lung comprising:

generating a flow of vapor;

expanding an expansion structure in a proximal portion of a targeted airway to occlude the airway;

introducing the flow of vapor into the lung distal to the expansion structure;

delivering thermal energy to the lung tissue via a vapor-to-liquid phase transition of the vapor; and

modifying the lung tissue to treat the disorder.

23. The method of claim 22 wherein the expansion structure directs the flow of vapor toward extremities of the targeted airway.

24. The method of claim 22 wherein introducing the flow of vapor includes introducing the flow over a sufficiently short interval to substantially prevent, conductive heat transfer to body structure external to a targeted airway.

25. The method of claim 22 wherein modifying lung tissue includes at least one of shrinkage, denaturation, damage, ablation, sealing, occlusion, an immune response or remodeling of lung tissue.

26. The method of claim 22 wherein the disorder of the lung comprises emphysema.

27. The method of claim 22 wherein the lung tissue includes at least one of bronchi, bronchioles, alveoli, parenchyma, diseased lung tissue, normal lung tissue, collagenous lung tissue and interalveolar collateral ventilation tissue.