Preventing transfusion related complications in a recipient of a blood transfusion

• US 7,892,535 B2
• Filed: 12/03/2009
• Issued: 02/22/2011
• Est. Priority Date: 06/02/2000
• Status: Expired due to Fees

• Current Assignee: Terumo BCT Biotechnologies, LLC (Terumo Corporation)
• Original Assignee: Caridianbct Biotechnologies LLC (Baxter International Inc.)
• Inventors: Li, Junzhi, Goodrich, Raymond P.
• Primary Examiner(s): Noakes; Suzanne M
• Assistant Examiner(s): Lee; Jae W
• Application Number:
  US12/630,505
• Publication Number:
  US 20100080781A1
• Time in Patent Office: 446 Days
• Field of Search: None
• US Class Current: 424/93.72
• CPC Class Codes: A01N 1/0215 Disinfecting agents, e.g. antimicrobials for preserving living parts
• CPC Class Codes: A01N 1/0226 Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/525 Isoalloxazines, e.g. riboflavins, vitamin B2
• CPC Class Codes: A61K 35/14 Blood; Artificial blood perfluorocarbons A61K31/02; umbilical cord blood A61K35/51; haemoglobin A61K38/42
• CPC Class Codes: A61K 35/19 Platelets; Megacaryocytes
• CPC Class Codes: A61K 41/0023 Agression treatment or altering

Abstract

This invention is directed toward a process for reducing transfusion related complications in a recipient of an allogeneic blood transfusion by adding to the blood to be transfused a photosensitizer comprising riboflavin, irradiating the blood and riboflavin with light, transfusing the irradiated blood into a recipient, and reducing a transfusion related complication by the recipient to cells in the donor blood.

The invention is also directed towards a process for preventing rejection of a donor organ by a recipient comprising the steps of transfusing the recipient of the donor organ with treated platelets; and transplanting the donor organ into the recipient.

Claims

1. A process for reducing rejection of a donor organ by a recipient comprising the steps of:

transfusing the recipient of the donor organ with platelets treated with a photosensitizer consisting essentially of riboflavin at a concentration of 50 μ

M and light at a wavelength between 290-370 nm for around 8 minutes,

wherein the recipient is transfused with the treated platelets for a period of time before receiving the donor organ; and

transplanting the donor organ into the recipient.

2. The process of claim 1 wherein the step of transfusing is repeated multiple times before the organ transplant.

3. The process of claim 1 wherein the donor organ to be transplanted into the recipient is allogeneic.

4. The process of claim 1 wherein the donor organ to be transplanted into the recipient is xenogeneic.

5. The process of claim 1 wherein the treated platelets are from an allogeneic donor.

6. The process of claim 1 wherein the treated platelets reduce the development of antibodies to the transplanted organ in the transplant recipient.

7. The process of claim 1 wherein the donor organ is a solid organ.

8. The process of claim 7 wherein the donor organ is a heart.