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System for seizure suppression

  • US 7,892,764 B2
  • Filed: 11/21/2007
  • Issued: 02/22/2011
  • Est. Priority Date: 11/21/2006
  • Status: Active Grant
First Claim
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1. A method of screening for anti-seizure drugs, comprising:

  • testing a library of compounds for an ability to inhibit an ion channel activity of at least one acid sensing ion channel (ASIC) at a pH that activates the ASIC;

    selecting one or more compounds from the library that have the ability to inhibit in a manner selective or specific for the ASIC relative to most or all ion channels that are not ASICs; and

    assaying the one or more compounds for inhibition of seizure-like electrical activity and/or seizures.

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