×

Humanized antibodies that recognize beta amyloid peptide

  • US 7,893,214 B2
  • Filed: 08/20/2007
  • Issued: 02/22/2011
  • Est. Priority Date: 12/02/1997
  • Status: Expired due to Fees
First Claim
Patent Images

1. A humanized immunoglobulin that binds to Aβ

  • comprising a humanized immunoglobulin light chain comprising (i) three variable region complementarity determining regions (CDRs) from the 3D6 immunoglobulin light chain variable region sequence of set forth as SEQ ID NO;

    2, and (ii) a variable framework region from a human acceptor immunoglobulin light chain sequence, provided that at least one framework residue is substituted with the corresponding amino acid residue from the mouse 3D6 light chain variable region sequence, wherein the framework residue is selected from the group consisting of;

    (a) a residue that non-covalently binds antigen directly;

    (b) a residue adjacent to a CDR;

    (c) a CDR-interacting residue; and

    (d) a residue participating in the VL-VH interface; and

    a humanized immunoglobulin heavy chain comprising (i) three variable region complementarity determining regions (CDRs) from the 3D6 immunoglobulin heavy chain variable region sequence set forth as SEQ ID NO;

    4, and (ii) a variable framework region from a human acceptor immunoglobulin heavy chain, provided that at least one framework residue is substituted with the corresponding amino acid residue from the mouse 3D6 heavy chain variable region sequence, wherein the framework residue is selected from the group consisting of;

    (a) a residue that non-covalently binds antigen directly;

    (b) a residue adjacent to a CDR;

    (c) a CDR-interacting residue; and

    (d) a residue participating in the VL-VH interface.

View all claims
  • 14 Assignments
Timeline View
Assignment View
    ×
    ×