Nucleic acids encoding the GPCR, RUP3, and methods of use thereof
First Claim
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1. An isolated nucleic acid which encodes a G protein-coupled receptor, wherein said nucleic acid comprises SEQ ID NO:
- 7.
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Abstract
The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors.
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20 Claims
- 1. An isolated nucleic acid which encodes a G protein-coupled receptor, wherein said nucleic acid comprises SEQ ID NO:
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2. An isolated nucleic acid which encodes a G protein-coupled receptor, wherein said G protein-coupled receptor comprises the amino acid sequence of SEQ ID NO:
- 8.
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3. An isolated nucleic acid which encodes a G protein coupled receptor, wherein said G protein-coupled receptor comprises the amino acid sequence of a mutant of SEQ ID NO:
- 8 comprising a substitution of lysine for leucine at amino acid position 224 of SEQ ID NO;
8.
- 8 comprising a substitution of lysine for leucine at amino acid position 224 of SEQ ID NO;
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4. An isolated nucleic acid which encodes a G protein-coupled receptor with at least 95% amino acid sequence identity to SEQ ID NO:
- 8, wherein said G protein-coupled receptor is capable of modulating insulin or glucagon levels.
- View Dependent Claims (5, 6, 7)
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8. An isolated nucleic acid which encodes a G protein-coupled receptor with at least 95% amino acid sequence identity to SEQ ID NO:
- 8, wherein said G protein-coupled receptor is a RUP3 protein.
- View Dependent Claims (9, 10, 11)
Specification