System and method for ischemia classification with implantable medical device

• US 7,894,884 B2
• Filed: 01/31/2007
• Issued: 02/22/2011
• Est. Priority Date: 01/31/2007
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Warman, Eduardo N., Musley, Shailesh K. V., Song, Zhendong, Lu, Steven N.
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): MALAMUD, DEBORAH LESLIE
• Application Number:
  US11/669,357
• Publication Number:
  US 20080183086A1
• Time in Patent Office: 1,483 Days
• Field of Search: 600508-509, 600/521, 128/920, 128/923
• US Class Current: 600/509
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: Y10S 128/92 Computer assisted medical diagnostics
• CPC Class Codes: Y10S 128/923 by comparison of patient data to other data

Abstract

An implantable medical device monitors ST segment data collected from EGM. ST trends are established and monitored over time. The IMD is able to discern whether the data indicate supply ischemia, demand ischemia, or other physiological causes. The IMD is then able to provide appropriate information and alerts.

Claims

1. A method comprising:

obtaining an electrogram representing cardiac data from an implantable medical device for a plurality of cardiac cycles;

determining an ST segment data point for each of the cardiac cycles;

initiating a timer interval when one of the ST segment data point values exceeds a threshold value;

determining a maximum ST segment data point value during the timer interval;

determining an amount of time from initiation of the timer interval until the maximum ST segment data point value occurs; and

determining whether the ST segment data points indicate ischemia based on the amount of time.

2. The method of claim 1, further comprising determining whether the ST segment data points indicate demand ischemia.

3. The method of claim 1, wherein determining an ST segment data point further comprises:

identifying a peak of an R wave;

adding a predetermined time interval to the identified peak; and

identifying a recorded value at a time identified by the predetermined time interval after the peak of the R wave as the ST segment data point.

4. The method of claim 3, further comprising:

determining a PR isoelectric baseline value; and

subtracting the PR isoelectric baseline value from the recorded value to identify the ST segment data point.

5. The method of claim 1, further comprising:

determining whether the ST segment data points indicate supply ischemia.

6. The method of claim 5, further comprising:

determining that the ST segment data points do not indicate supply ischemia if the amount of time is less than a first short value or greater than a first long value.

7. The method of claim 5, further comprising:

determining that the ST segment data points do not indicate supply ischemia if less than a predetermined percentage of the ST segment data points occurring during the timer interval exceed the threshold value.

8. The method of claim 5, further comprising:

determining that the ST segment data points do not indicate supply ischemia if an ST segment data point occurring at a termination of the timer interval is less than a predetermined percentage of the maximum ST segment data point value.

9. The method of claim 5, further comprising:

calculating a slope of the ST segment data points prior to the maximum ST segment data point; and

determining that the ST segment data points do not indicate supply ischemia if the slope is less than a first slope value.

10. The method of claim 5, further comprising evaluating a secondary indicator to confirm the determination of whether the ST segment data points indicate supply ischemia.

11. The method of claim 1, further comprising:

monitoring the ST segment data point values; and

processing the values using a predetermined filter bank.

12. The method of claim 1, further comprising:

monitoring the ST segment data point values; and

processing the values by comparing to a template.

13. An apparatus comprising:

means for obtaining an electrogram representing cardiac data from an implantable medical device for a plurality of cardiac cycles;

means for determining an ST segment data point for each of the cardiac cycles;

means for initiating a timer interval when one of the ST segment data point values exceeds a threshold value;

means for determining a maximum ST segment data point value during the timer interval;

means for determining an amount of time from initiation of the timer interval until the maximum ST segment data point value occurs; and

means for determining whether the ST segment data points indicate ischemia based on the amount of time.

14. The apparatus of claim 13, further comprising means for determining whether the ST segment data points indicate demand ischemia.

15. The apparatus of claim 13, wherein the means for determining an ST segment data point further comprise:

means for identifying a peak of an R wave;

means for adding a predetermined time interval to the identified peak; and

means for identifying a recorded value at a time identified by the predetermined time interval after the peak of the R wave as the ST segment data point.

16. The apparatus of claim 15, further comprising:

means for determining a PR isoelectric baseline value; and

means for subtracting the PR isoelectric baseline value from the recorded value to identify the ST segment data point,

17. The apparatus of claim 13, further comprising:

means for determining whether the ST segment data points indicate supply ischemia.

18. The apparatus of claim 17, further comprising:

means for determining that the ST segment data points do not indicate supply ischemia if the amount of time is less than a first short value or greater than a first long value.

19. The apparatus of claim 17, further comprising:

means for determining that the ST segment data points do not indicate supply ischemia if less than a predetermined percentage of the ST segment data points occurring during the timer interval exceed the threshold value.

20. The apparatus of claim 17, further comprising:

means for determining that the ST segment data points do not indicate supply ischemia if an ST segment data point occurring at a termination of the timer interval is less than a predetermined percentage of the maximum ST segment data point value.

21. The apparatus of claim 17, further comprising:

means for calculating a slope of the ST segment data points prior to the maximum ST segment data point; and

means for determining that the ST segment data points do not indicate supply ischemia if the slope is less than a first slope value.

22. The apparatus of claim 17, further comprising means for evaluating a secondary indicator to confirm the determination of whether the ST segment data points indicate supply ischemia.

23. An apparatus comprising:

a sensor input that obtains an electrogram representing cardiac data for a plurality of cardiac cycles;

an electrogram analysis module that determines an ST segment data point for each of the cardiac cycles; and

an ST analysis module that;

initiates a timer interval when one of the ST segment data point values exceeds a threshold value;

determines a maximum ST segment data point value during the timer interval;

determines an amount of time from initiation of the timer interval until the maximum ST segment data point value occurs; and

determines whether the ST segment data points indicate ischemia based on the amount of time.

24. The apparatus of claim 23, wherein the ST analysis module determines whether the ST segment data points indicate demand ischemia.

25. The apparatus of claim 23, wherein the electrogram analysis module:

identifies a peak of an R wave;

adds a predetermined time interval to the identified peak; and

identifies a recorded value at a time identified by the predetermined time interval after the peak of the R wave as the ST segment data point.

26. The apparatus of claim 25, wherein the electrogram analysis module:

determines a PR isoelectric baseline value; and

subtracts the PR isoelectric baseline value from the recorded value to identify the ST segment data point.

27. The apparatus of claim 23, wherein the ST analysis module determines whether the ST segment data points indicate supply ischemia.

28. The apparatus of claim 27, wherein the ST analysis module determines that the ST segment data points do not indicate supply ischemia if the amount of time is less than a first short value or greater than a first long value.

29. The apparatus of claim 27, wherein the ST analysis module determines that the ST segment data points do not indicate supply ischemia if less than a predetermined percentage of the ST segment data points occurring during the timer interval exceed the threshold value.

30. The apparatus of claim 27, wherein the ST analysis module determines that the ST segment data points do not indicate supply ischemia if an ST segment data point occurring at a termination of the timer interval is less than a predetermined percentage of the maximum ST segment data point value.

31. The apparatus of claim 27, wherein the ST analysis module:

calculates a slope of the ST segment data points prior to the maximum ST segment data point; and

determines that the ST segment data points do not indicate supply ischemia if the slope is less than a first slope value.

32. The apparatus of claim 27, wherein the ST analysis module evaluates a secondary indicator to confirm the determination of whether the ST segment data points indicate supply ischemia.