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System and method for testing neural stimulation threshold

  • US 7,894,895 B2
  • Filed: 08/23/2010
  • Issued: 02/22/2011
  • Est. Priority Date: 04/10/2006
  • Status: Expired due to Fees
First Claim
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1. A method for modulating autonomic balance between parasympathetic tone and sympathetic tone in an autonomic nervous system (ANS), the method comprising:

  • stimulating an autonomic neural target to modulate the autonomic balance in the ANS;

    performing a neural stimulation threshold test in response to a demand for the neural stimulation threshold test, wherein performing the neural stimulation threshold test includes;

    inducing a premature ventricular contraction (PVC) event or detecting an intrinsic PVC event;

    detecting pre-PVC heart rate data and post-PVC heart rate data;

    measuring heart rate turbulence (HRT) in response to the PVC event using the pre-PVC heart rate data and the post-PVC heart rate data to generate an autonomic balance indicator (ABI); and

    using the ABI to determine whether the neural stimulation signal evokes a response above a threshold.

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