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Low intensity directed ultrasound (LODUS) mediated blood brain barrier disruption

  • US 7,896,821 B1
  • Filed: 11/12/2004
  • Issued: 03/01/2011
  • Est. Priority Date: 11/14/2003
  • Status: Active Grant
First Claim
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1. A method of delivering a therapeutic or prophylactic agent through the blood-brain barrier of an animal body, comprising introducing said agent into the blood stream in the absence of exogenous bubble-forming agents and, in conjunction therewith, transiently disrupting a region of the blood-brain barrier by applying thereto low intensity directed unfocused ultrasound (LODUS) having a mechanical index of less than 1 and a frequency of less than 1.0 megahertz (MHz) to facilitate passage of said therapeutic or prophylactic agent from the bloodstream and through the blood-brain barrier.

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