Computer controlled drug delivery system with dynamic pressure sensing

• US 7,896,833 B2
• Filed: 09/02/2009
• Issued: 03/01/2011
• Est. Priority Date: 12/21/2006
• Status: Active Grant

• Current Assignee: Milestone Scientific Incorporated
• Original Assignee: Milestone Scientific Incorporated
• Inventors: Hochman, Mark N.
• Primary Examiner(s): Stigell; Theodore J
• Application Number:
  US12/552,723
• Publication Number:
  US 20090326482A1
• Time in Patent Office: 545 Days
• Field of Search: 604 65- 67, 604/131, 604/151, 604/93.01, 604/246, 604/890.1
• US Class Current: 604/65
• CPC Class Codes: A61C 1/0015 Electrical systems
• CPC Class Codes: A61C 19/08 combined with anaesthetising implements dental hypodermic syringes A61M5/00
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/2488 via rotation, e.g. threads or bayonet
• CPC Class Codes: A61M 2205/3344 Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/582 by tactile feedback
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion
• CPC Class Codes: A61M 5/48 having means for varying, regulating, indicating or limiting injection pressure A61M5/142 takes precedence ; monitoring pressure in infusion systems A61M5/16854

Abstract

Apparatus administers dental anesthetic to intraligamentary tissue with a drive unit and handpiece with injection needle connected by flexible tube to the unit. The drug is passes to the tissue at an instantaneous pressure at the needle tip that varies due to placement. A minimum threshold pressure is desired for administering the drug to the tissue. A practitioner moves the handpiece to insert the needle tip near the intraligamentary tissue and the instantaneous pressure is sensing or calculating. An auditory ascending signal indicates when the instantaneous pressure is rising, and when the instantaneous pressure reaches the threshold pressure a perceptible auditory specific signal indicates the practitioner has moved the tip into intraligamentary tissue. The tip is then maintained for supplying a selected dosage of the drug. Another auditory signal notifies the practitioner that the instantaneous pressure is declining or fluctuating before reaching the minimum threshold pressure.

Claims

1. An apparatus for a practitioner to administer a controlled injection of a dental anesthetic drug into intraligamentary tissue of a subject, the apparatus comprising:

a drive unit for supplying the drug at least one flow rate;

a handpiece for being held by the practitioner, the handpiece being connected to the drive unit by a flexible tube for receiving the drug, the handpiece carrying an injection needle to be inserted into the subject near the intraligamentary tissue of the subject, the injection needle having a tip for passing the drug to the subject at an instantaneous and at an absolute pressure that is at the tip of the injection needle, and that varies due to a placement of the needle tip in the subject, there being a minimum threshold pressure of about 200 to 500 psi and an absolute pressure which is desired for administering the drug to the intraligamentary tissue;

a computer connected to the drive unit and programmed for operating the drive unit for supplying the dental anesthetic drug to the injection needle at a selected flow rate while the practitioner holds the handpiece, the tip of the needle adapted to be inserted into the subject at a location near the intraligamentary tissue of the subject for passing the drug to the subject near the intraligamentary tissue at the instantaneous and absolute pressure that is at the tip of the needle and that varies in real-time as a function of the intraligamentary tissue and a placement of the tip of the needle;

a pressure sensor connected to the computer for sensing or calculating the instantaneous pressure on a real-time basis;

a sound generator connected to the computer, the computer being programmed for driving the sound generator for supplying a perceptible auditory ascending signal to the practitioner that indicates when the instantaneous pressure is rising toward the minimum threshold pressure, for guiding movement of the placement of the tip of the needle by the practitioner at least until the minimum threshold pressure has been reached;

the computer being programmed for driving the sound generator for supplying a perceptible auditory specific signal to the practitioner that indicates when the instantaneous pressure has reached the minimum threshold pressure which indicates that the practitioner has moved the tip of the needle into the intraligamentary tissue and so that after the perceptible auditory specific signal is supplied, the practitioner maintains the tip of the needle in the intraligamentary tissue for supplying a selected dosage of the drug to the intraligamentary tissue at the selected flow rate; and

the computer also being programmed for driving the sound generator for notifying the practitioner by generating a perceptible auditory signal when the instantaneous pressure declines or fluctuates before reaching the minimum threshold pressure.

2. The apparatus according to claim 1, including a visual scale connected to the computer and the computer being programmed to drive the visual scale for supplying to the practitioner a visual signal which includes a plurality of signals that correspond to different real-time values for the instantaneous pressure before it has reached the minimum threshold pressure, and at least one visual signal that indicates that the instantaneous pressure has reached the minimum threshold pressure.

3. The apparatus according to claim 1, wherein the computer is programmed for driving the sound generator for supplying to the practitioner a further perceptible signal when the instantaneous pressure is above a selected over-pressure to indicate to the practitioner that an undesirable over-pressure condition has occurred.

4. The apparatus according to claim 1, wherein the minimum threshold pressure is in the range of about 200 to 500 psi and the selected flow rate is at least about 0.002 ml/sec.