Two-compartment reduced volume infusion pump

• US 7,896,865 B2
• Filed: 09/30/2003
• Issued: 03/01/2011
• Est. Priority Date: 09/30/2003
• Status: Active Grant

• Current Assignee: Codman & Shurtleff Incorporated (Johnson & Johnson)
• Original Assignee: Codman & Shurtleff Incorporated (Johnson & Johnson)
• Inventors: Kulessa, Sigmund
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): Bouchelle; Laura A
• Application Number:
  US10/676,326
• Publication Number:
  US 20050070875A1
• Time in Patent Office: 2,709 Days
• Field of Search: 604/890.1, 604/891.1, 604/892.1, 604/65, 604/66
• US Class Current: 604/890.1
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 5/1407 Infusion of two or more substances
• CPC Class Codes: A61M 5/141 with capillaries for restricting fluid flow
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/427 Locating point where body is to be pierced, e.g. vein location means using ultrasonic waves, injection site templates
• CPC Class Codes: B01F 25/433 Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
• CPC Class Codes: B01F 25/4331 Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow

Abstract

An implantable infusion apparatus has a medication reservoir for storing a medication and a carrier reservoir for storing a carrier. The entire apparatus, including both reservoirs, is typically located in a housing made of stainless steel, titanium, or any other strong corrosion resistant biocompatible material. The medication and carrier reservoirs are accessed through a medication access port and a carrier access port, respectively. The access ports are covered with a medication compound septum and a carrier compound septum, respectively. The carrier reservoir is larger, and thus holds a larger volume, than the medication reservoir. To reduce the size of the implantable infusion apparatus, the medication is highly concentrated to many times the dosage required. The concentrated medication is then diluted with the carrier, to the proper dose, before it is discharged to the patient.

Claims

1. An infusion apparatus implantable in a human body, comprising:

a medication reservoir for storing a medication;

a carrier reservoir for storing a carrier, wherein the carrier reservoir is larger than the medication reservoir;

a mixing chamber in which the medication and carrier are thoroughly mixed, thus diluting the medication with the carrier, said mixing chamber being a micro fluidic chip having a capillary pathway disposed in a serpentine pattern;

a medication flow path fluidly connecting the medication reservoir to the mixing chamber;

a carrier flow path fluidly connecting the carrier reservoir to the mixing chamber;

a medication pump system for discharging the medication to the mixing chamber;

a carrier pump system for discharging the carrier to the mixing chamber;

an outlet port fluidly connected to the mixing chamber for discharging a diluted medication/carrier mixture; and

a bolus port disposed between the mixing chamber and the outlet port.

2. The implantable infusion apparatus of claim 1, further comprising:

a medication flow restrictor disposed in the medication flow path to restrict a flow of the medication between the medication reservoir and the mixing chamber.

3. The implantable infusion apparatus of claim 2, wherein the medication flow restrictor is a micro fluidic chip.

4. The implantable infusion apparatus of claim 1, further comprising:

a carrier flow restrictor disposed in the carrier flow path to restrict a flow of the carrier between the carrier reservoir and the mixing chamber.

5. The implantable infusion apparatus of claim 4, further comprising:

a medication flow restrictor disposed in the medication flow path to restrict a flow of the medication between the medication reservoir and the mixing chamber.

6. The implantable infusion apparatus of claim 4, wherein the carrier flow restrictor is a microfluidic chip.

7. The implantable infusion apparatus of claim 5, wherein the medication flow restrictor is more restrictive than the carrier flow restrictor.

8. The implantable infusion apparatus of claim 5, wherein the medication flow restrictor is less restrictive than the carrier flow restrictor.

9. The implantable infusion apparatus of claim 1, wherein the medication flow path is more restrictive than the carrier flow path.

10. The implantable infusion apparatus of claim 1, wherein the medication flow path is less restrictive than the carrier flow path.

11. The implantable infusion apparatus of claim 1, wherein the medication pump system has a medication discharge rate and the carrier pump system has a carrier discharge rate, and the medication discharge rate is greater than the carrier discharge rate.

12. The implantable infusion apparatus of claim 1, wherein the medication pump system has a medication discharge rate, and the carrier pump system has a carrier discharge rate and the medication discharge rate is less than the carrier discharge rate.

13. The implantable infusion apparatus of claim 1, wherein the medication pump system and the carrier pump system comprises a power cell selected from the group consisting of a two-phase fluid power cell associated with the medication and the carrier reservoirs, the fluid in the power cell vaporizing at physiological temperatures and a gas pressurized power cell charged with a propellant.

14. The implantable infusion apparatus of claim 1, wherein the medication pump system and the carrier pump system comprises a battery operated system.

15. The implantable infusion apparatus of claim 1, further comprising a housing enclosing the implantable infusion apparatus wherein the housing is sized to be implantable in the human body.

16. The implantable infusion apparatus of claim 1, further comprising:

a medication access port to access the medication reservoir and covered with a medication compound septum; and

a carrier access port to access the carrier reservoir and covered with a carrier compound septum.

17. An implantable infusion apparatus comprising:

a medication reservoir for storing a medication;

a carrier reservoir for storing a carrier, wherein the carrier reservoir is larger than the medication reservoir;

a mixing chamber in which the medication may be mixed with and diluted by the carrier, said mixing chamber being a microfluidic chip having a capillary pathway disposed in a serpentine pattern;

a medication flow path fluidly connecting the medication reservoir to the mixing chamber;

a carrier flow path fluidly connecting the carrier reservoir to the mixing chamber;

a medication pump system for discharging the medication into the mixing chamber;

a carrier pump system for discharging the carrier into the mixing chamber;

an electronically controlled medication flow selector disposed in the medication flow path for controlling a discharge rate of the medication to the mixing chamber;

an outlet port fluidly connected to mixing chamber for discharging a diluted medication/carrier mixture; and

a bolus port disposed between the mixing chamber and the outlet port.

18. The implantable infusion apparatus of claim 17, wherein the medication flow selector is one of a valve and a pump.

19. The implantable infusion apparatus of claim 17, wherein the medication flow selector further comprises a controller for altering the medication discharge rate.

20. The implantable infusion apparatus of claim 17, further comprising:

an electronically controlled carrier flow selector disposed in the carrier flow path for controlling a discharge rate of the carrier to the mixing chamber.

21. The implantable infusion apparatus of claim 20, wherein the carrier flow selector is one of a valve and a pump.

22. The implantable infusion apparatus of claim 20, wherein the carrier flow selector further comprises a controller for altering the carrier discharge rate.

23. The implantable infusion apparatus of claim 17, further comprising:

a medication flow restrictor disposed in the medication flow path prior to the medication flow selector for restricting the flow of the medication between the medication reservoir and the mixing chamber.

24. The implantable infusion apparatus of claim 23, further comprising:

a medication flow restrictor disposed in the medication flow path prior to the medication flow selector to restrict the flow of the medication between the medication reservoir and the medication flow selector.

25. The implantable infusion apparatus of claim 23, wherein the medication flow restrictor is a micro fluidic chip.

26. The implantable infusion apparatus of claim 17, further comprising:

a carrier flow restrictor disposed in the carrier flow path to restrict the flow of the carrier between the carrier reservoir and the mixing chamber.

27. The implantable infusion apparatus of claim 26, wherein the medication flow restrictor is more restrictive than the carrier flow restrictor.

28. The implantable infusion apparatus of claim 26, wherein the medication flow restrictor is less restrictive than the carrier flow restrictor.

29. The implantable infusion apparatus of claim 26, wherein the carrier flow restrictor is a microfluidic chip.

30. The implantable infusion apparatus of claim 17, wherein the medication flow path is more restrictive than the carrier flow path.

31. The implantable infusion apparatus of claim 17, wherein the medication flow path is less restrictive than the carrier flow path.

32. The implantable infusion apparatus of claim 17, wherein the carrier pump system has a carrier discharge rate and the medication discharge rate is greater than the carrier discharge rate.

33. The implantable infusion apparatus of claim 17, wherein the carrier pump system has a carrier discharge rate and the medication discharge rate is less than the carrier discharge rate.

34. The implantable infusion apparatus of claim 17, wherein the medication pump system and the carrier pump system comprises a power cell selected from the group consisting of a two-phase fluid power cell associated with the medication and the carrier reservoirs, the fluid in the power cell vaporizing at physiological temperatures and a gas pressurized power cell charged with a propellant.

35. The implantable infusion apparatus of claim 17, wherein the medication pump system and the carrier pump system comprises a battery operated system.

36. The implantable infusion apparatus of claim 17, further comprising a housing enclosing the implantable infusion apparatus wherein the housing is sized to be implantable in the human body.

37. The implantable infusion apparatus of claim 17, further comprising:

a medication access port to access the medication reservoir and covered with a medication compound septum; and

a carrier access port to access the carrier reservoir and covered with a carrier compound septum.

38. A method of infusing medication comprising:

storing a medication in a medication reservoir;

storing a carrier in a carrier reservoir, wherein the carrier reservoir is larger than the medication reservoir;

discharging the medication to a mixing chamber;

discharging the carrier to the mixing chamber;

mixing the medication with the carrier in the mixing chamber to dilute medication and form a medication/carrier mixture, wherein the mixing chamber is a micro fluidic chip having a capillary pathway disposed in a serpentine pattern;

discharging the diluted medication/carrier mixture; and

introducing a bolus dosage into the diluted medication/carrier mixture prior to discharging the diluted medication/carrier mixture.

39. The method of claim 38, further comprising:

restricting the discharge of the medication.

40. The method of claim 38, further comprising:

restricting the discharge of the carrier.

41. The method of claim 40, further comprising:

restricting the discharge of the medication.

42. The method of claim 41, further comprising:

restricting the discharge of the medication more than the discharge of the carrier.

43. The method of claim 41, further comprising:

restricting the discharge of the carrier more than the discharge of the medication.

44. The method of claim 38, wherein the mixing step comprises:

contacting the medication with the carrier in the mixing chamber;

flowing a contacted medication/carrier mixture through a series of mixing elements; and

delaying the discharging of the diluted medication/carrier mixture until the medication is diluted to the proper dosage.

45. A method of infusing medication comprising:

storing a medication in a medication reservoir;

storing a carrier in a carrier reservoir, wherein the carrier reservoir is larger than the medication reservoir;

controlling the discharge of the medication into a mixing chamber;

discharging the carrier into the mixing chamber;

mixing the medication with the carrier in the mixing chamber to dilute it to form a diluted medication/carrier mixture, wherein the mixing chamber is a micro fluidic chip having a capillary pathway disposed in a serpentine pattern;

discharging the diluted medication/carrier mixture; and

introducing a bolus dosage into the diluted medication/carrier mixture prior to discharging the diluted medication/carrier mixture.

46. The method of claim 45, further comprising:

restricting the discharge of the medication.

47. The method of claim 45, further comprising:

restricting the discharge of the carrier.

48. The method of claim 45, further comprising:

restricting the discharge of the medication.

49. The method of claim 48, further comprising:

restricting the discharge of the medication more than the discharge of the carrier.

50. The method of claim 48, further comprising:

restricting the discharge of the carrier more than the discharge of the medication.

51. The method of claim 45, wherein the mixing step comprises:

contacting the medication with the carrier in the mixing chamber;

flowing a contacted medication/carrier mixture through a series of mixing elements; and

delaying the discharging step until the medication is diluted to the proper dosage.