Low oxygen in vivo analyte sensor
First Claim
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1. A glucose sensor system comprising:
- an electrode configured to measure a concentration of glucose in a host, wherein the electrode comprises an exposed electroactive surface with an area of from about 0.000084 cm2 to about 0.016 cm2;
a membrane disposed over the electrode and configured to limit transport of glucose to the electrode; and
sensor electronics operably connected to the electrode and configured to measure a current flow associated with the electrode, wherein the sensor electronics are configured to measure the current flow in at least a picoAmp range;
wherein the system is configured to have a glucose sensitivity of from about 1 pA/mg/dL to about 25 pA/mg/dL, and wherein the system is configured to measure the current flow associated with the electrode with substantial linearity at glucose concentrations of up to about 400 mg/dL in a fluid with an oxygen concentration of less than about 0.6 mg/L.
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Abstract
The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.
941 Citations
41 Claims
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1. A glucose sensor system comprising:
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an electrode configured to measure a concentration of glucose in a host, wherein the electrode comprises an exposed electroactive surface with an area of from about 0.000084 cm2 to about 0.016 cm2; a membrane disposed over the electrode and configured to limit transport of glucose to the electrode; and sensor electronics operably connected to the electrode and configured to measure a current flow associated with the electrode, wherein the sensor electronics are configured to measure the current flow in at least a picoAmp range; wherein the system is configured to have a glucose sensitivity of from about 1 pA/mg/dL to about 25 pA/mg/dL, and wherein the system is configured to measure the current flow associated with the electrode with substantial linearity at glucose concentrations of up to about 400 mg/dL in a fluid with an oxygen concentration of less than about 0.6 mg/L. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A glucose sensor system comprising:
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an electrode configured to measure a concentration of glucose in a host; a membrane disposed over the electrode and configured to limit transport of glucose to the electrode; and sensor electronics operably connected to the electrode and configured to measure a current flow associated with the electrode; wherein the system is configured to accurately measure glucose concentrations of up to about 400 mg/dL in a fluid with an oxygen concentration of less than about 0.6 mg/L, and wherein the system is configured to have a glucose sensitivity of from about 1 pA/mg/dL to about 25 pA/mg/dL. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A glucose sensor system comprising:
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an electrode configured to measure a concentration of glucose in a host; a membrane disposed over the electrode and configured to limit transport of glucose to the electrode; and sensor electronics operably connected to the electrode and configured to measure a current flow associated with the electrode; wherein the system is configured to have a glucose sensitivity of from about 1 pA/mg/dL to about 100 pA/mg/dL, and wherein the system is configured to accurately measure glucose concentrations of up to about 400 mg/dL in a fluid with an oxygen concentration of less than about 0.3 mg/L. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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Specification