Calibration of optical analysis making use of multivariate optical elements
First Claim
1. A method of calibrating an optical analysis system being adapted to determine an amplitude of a principal component of an optical signal by making use of a multivariate optical element and a detector, the method of calibrating comprising the acts of:
- determining the principal component of the optical signal being obtained from a first reference sample;
deriving at least a first parameter of the first reference sample by making use of the principal component;
performing a comparison between the at least first parameter with at least a first reference parameter of the first reference sample;
determining at least a first calibration value for the at least first parameter by making use of the comparison, the at least first calibration value being applicable for calibrating the optical analysis system; and
deriving an at least second parameter of the optical analysis system from an output signal of the detector in absence of the first reference sample and/or in absence of optical radiation, the at least second parameter being representative of system inherent noise and being applicable for calibrating the optical analysis system.
1 Assignment
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Accused Products
Abstract
A method of calibrating an optical analysis system uses multivariate optical signal analysis. The method includes determining a parameter of a reference sample, and comparing the actually determined parameter with a reference parameter that represents a precise and real property of the reference sample. Based on the comparison, a calibration value is determined that is applicable to perform a calibration of the optical analysis system with respect to at least one compound or analyte of the reference sample. Parameters and reference parameters of a reference sample may refer to a concentration of an analyte dissolved in the sample, or to spectroscopic background signals that have to be taken into account when performing a spectral analysis based on optical signals obtained from the reference sample. Analyte-specific reference data is stored in a calibration unit of the optical analysis system and allows a high degree of automation of the calibration process.
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Citations
13 Claims
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1. A method of calibrating an optical analysis system being adapted to determine an amplitude of a principal component of an optical signal by making use of a multivariate optical element and a detector, the method of calibrating comprising the acts of:
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determining the principal component of the optical signal being obtained from a first reference sample; deriving at least a first parameter of the first reference sample by making use of the principal component; performing a comparison between the at least first parameter with at least a first reference parameter of the first reference sample; determining at least a first calibration value for the at least first parameter by making use of the comparison, the at least first calibration value being applicable for calibrating the optical analysis system; and deriving an at least second parameter of the optical analysis system from an output signal of the detector in absence of the first reference sample and/or in absence of optical radiation, the at least second parameter being representative of system inherent noise and being applicable for calibrating the optical analysis system. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of calibrating an optical analysis system being adapted to determine an amplitude of a principal component of an optical signal by making use of a multivariate optical element and a detector, the method of calibrating comprising the acts of:
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determining the principal component of the optical signal being obtained from a first reference sample; deriving at least a first parameter of the first reference sample by making use of the principal component; performing a comparison between the at least first parameter with at least a first reference parameter of the reference sample; determining at least a first calibration value for the at least first parameter by making use of the comparison, the at least first calibration value being applicable for calibrating the optical analysis system; calibrating the optical analysis system by the at least a first calibration value; repeatedly deriving at least a third parameter of the first reference sample by making use of the principal component; and repeatedly performing a comparison between the at least third parameter with the at least first reference parameter of the first reference sample in order to provide a feedback of a quality of the calibration.
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8. A computer program product for calibrating an optical analysis system for determining an amplitude of a principal component of an optical signal by making use of a multivariate optical element and a detector, the computer program product being executable by a processing unit of the optical analysis system and being operable to:
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determine the principal component of the optical signal being obtained from a first reference sample; derive at least a first parameter of the first reference sample by making use of the principal component; perform a comparison between the at least first parameter with at least a first reference parameter of the first reference sample; determine at least a first calibration value for the at least first parameter by making use of the comparison, the at least first calibration value being applicable for calibrating the optical analysis system; and derive an at least second parameter of the optical analysis system from an output signal of the detector in absence of the first reference sample and/or in absence of optical radiation, the at least second parameter being representative of system inherent noise and being applicable for calibrating the optical analysis system.
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9. An optical analysis system being adapted to determine an amplitude of a principal component of an optical signal by making use of a multivariate optical element and a detector, the optical analysis system comprising:
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means for determining the principal component of the optical signal being obtained from a first reference sample; means for deriving at least a first parameter of the first reference sample by making use of the principal component; means for performing a comparison between the at least first parameter with at least a first reference parameter of the first reference sample; means for determining at least a first calibration value for the at least first parameter by making use of the comparison, the at least first calibration value being applicable for calibrating the optical analysis system; and means for deriving an at least second parameter of the optical analysis system from an output signal of the detector in absence of the first reference sample and/or in absence of optical radiation, the at least second parameter being representative of system inherent noise and being applicable for calibrating the optical analysis system. - View Dependent Claims (10)
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11. An optical analysis system being adapted to determine an amplitude of a principal component of an optical signal by making use of a multivariate optical element and a detector, the optical analysis system comprising:
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an analysis unit for determining the principal component of the optical signal being obtained from a first reference sample and for deriving at least a first parameter of the first reference sample by making use of the at least one principal component; a calibration unit for performing a comparison between the at least first parameter with at least a first reference parameter of the reference sample;
for determining at least a first calibration value for the at least first parameter by making use of the comparison, the at least first calibration value being applicable for calibrating the optical analysis system; and
for deriving an at least second parameter of the optical analysis system from an output signal of the detector in absence of the first reference sample and/or in absence of optical radiation, the at least second parameter being representative of system inherent noise and being applicable for calibrating the optical analysis system. - View Dependent Claims (12, 13)
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Specification