Cartilage allograft plug

• US 7,901,457 B2
• Filed: 05/16/2003
• Issued: 03/08/2011
• Est. Priority Date: 05/16/2003
• Status: Expired due to Term

• Current Assignee: Musculoskeletal Transplant Foundation
• Original Assignee: Musculoskeletal Transplant Foundation
• Inventors: Tomford, William W., Sunwoo, Moon Hae, Truncale, Katherine Gomes, Gertzman, Arthur A.
• Primary Examiner(s): RAMANA, ANURADHA
• Application Number:
  US10/438,883
• Publication Number:
  US 20040230303A1
• Time in Patent Office: 2,853 Days
• Field of Search: 623/11.11, 623/16.11, 623/17.11, 623/17.16, 623/23.56, 623/23.57, 623/23.58, 623/23.59, 623/23.6, 623/23.61, 623/23.62, 623/23.63, 623/14.12, 623/20.14
• US Class Current: 623/16.11
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/3859 Femoral components
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/2839 Bone plugs or bone graft dowels
• CPC Class Codes: A61F 2002/30004 the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30136 undulated or wavy, e.g. serpentine-shaped or zigzag-shaped
• CPC Class Codes: A61F 2002/30224 cylindrical
• CPC Class Codes: A61F 2002/30233 Stepped cylinders, i.e. having discrete diameter changes
• CPC Class Codes: A61F 2002/30235 tubular, e.g. sleeves
• CPC Class Codes: A61F 2002/30299 umbrella-shaped or mushroom-shaped
• CPC Class Codes: A61F 2002/30327 differing in diameter
• CPC Class Codes: A61F 2002/30764 Cartilage harvest sites
• CPC Class Codes: A61F 2002/30785 parallel
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2230/0004 Rounded shapes, e.g. with rounded corners
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2230/0093 Umbrella-shaped, e.g. mushroom-shaped
• CPC Class Codes: A61F 2250/0014 having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
• CPC Class Codes: A61F 2250/0039 : differing in diameter
• CPC Class Codes: A61F 2310/00365 : Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61F 2310/00383 : Gelatin
• CPC Class Codes: A61L 2430/06 : for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/3608 : Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/3612 : Cartilage, synovial fluid
• CPC Class Codes: A61L 27/3654 : Cartilage, e.g. meniscus
• CPC Class Codes: A61L 27/3683 : subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
• CPC Class Codes: A61L 27/3817 : Cartilage-forming cells, e.g. pre-chondrocytes
• CPC Class Codes: A61L 27/3821 : Bone-forming cells, e.g. osteoblasts, osteocytes, osteoprogenitor cells
• CPC Class Codes: A61L 27/3852 : Cartilage, e.g. meniscus

Abstract

The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.

Claims

1. A method of placing a preshaped allograft plug assembly in a cartilage defect, said assembly comprising a subchondral bone and an overlying cartilage cap which as been treated to remove cellular debris and proteoglycans and milled cartilage in a carrier comprising the steps of:

(a) cutting a first cylindrical bore in a patient at a site of a cartilage defect area to remove the cartilage defect;

(b) cutting a second cylindrical bore to having a diameter greater than the first cylindrical bore a depth which is substantially the same as the depth of a cartilage layer in the defect area to form a stepped bore;

(c) placing a mixture of milled cartilage in a bioabsorbable carrier in the formed hole; and

(d) placing a preshaped allograft osteochondral plug having a cross section which engages the walls defining said hole allowing the structure to be placed in an interference fit within said stepped bore with the surface of the cartilage cap being substantially flush with surrounding cartilage.

2. The method of claim 1 wherein the first cylindrical bore and the second cylindrical bore have the same axis.